Detailed information of TA system TA030563

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 131330..131979
• Replicon: chromosome
• Accession: NZ_AP012547
• Organism: Sulfuritalea hydrogenivorans sk43H strain DSM 22779

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SUTH_RS00605
• Protein ID: WP_041096275.1
• Coordinates: 131587..131979 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: W0SAN8
• Locus tag: SUTH_RS00600
• Protein ID: WP_041096272.1
• Coordinates: 131330..131590 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SUTH_RS19510	127119..129842	+	2724	WP_052473000.1	caspase family protein	-
SUTH_RS00595	130058..131236	+	1179	WP_084207195.1	radical SAM protein	-
SUTH_RS00600	131330..131590	+	261	WP_041096272.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SUTH_RS00605	131587..131979	+	393	WP_041096275.1	type II toxin-antitoxin system VapC family toxin	Toxin
SUTH_RS00610	132038..132298	+	261	WP_041096277.1	hypothetical protein	-
SUTH_RS00615	132360..133649	+	1290	WP_041096279.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
SUTH_RS00620	133612..134205	+	594	WP_041096281.1	DUF4390 domain-containing protein	-
SUTH_RS00625	134202..136322	+	2121	WP_041096283.1	HAMP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• SpoVT-AbrB domain (8-55)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14245.74 Da
• Isoelectric Point: 9.8009

>T30563 WP_041096275.1 NZ_AP012547:131587-131979 [Sulfuritalea hydrogenivorans sk43H]
VKRYMLDTNTVSHLIKAHPAVIRRVLAAPMASLCISAITEGELLFGLAKRPGAKRLHIAVRELLLRLDVLPWNSAEHYGM
ARAEMEAQGRILASLDLLIAAHALSVGAVLVTNDRAFRQVGGLQLEDWTT

Nucleotide

• Length: 393 bp

>T30563 NZ_AP012547:131587-131979 [Sulfuritalea hydrogenivorans sk43H]
GTGAAGCGCTACATGCTGGACACCAATACGGTGAGCCATCTGATCAAGGCGCATCCGGCCGTCATCCGTCGCGTGCTGGC
CGCGCCGATGGCATCGCTGTGCATTTCGGCCATCACCGAAGGCGAGTTGTTGTTTGGGCTGGCCAAGCGACCGGGAGCAA
AGCGGCTGCATATCGCCGTGCGCGAGCTTCTGCTGCGCCTCGATGTTCTGCCCTGGAACAGCGCCGAGCATTACGGAATG
GCGAGGGCCGAAATGGAGGCTCAGGGCCGGATTCTCGCATCGCTTGACCTGTTGATCGCCGCGCACGCCTTGAGCGTCGG
CGCGGTACTGGTCACCAATGATCGCGCCTTTCGTCAGGTCGGCGGATTGCAGCTTGAAGACTGGACAACGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9522.73 Da
• Isoelectric Point: 9.8629

>AT30563 WP_041096272.1 NZ_AP012547:131330-131590 [Sulfuritalea hydrogenivorans sk43H]
MSQVAKLFTNGRSQAVRLPAAYRFDTSEVFIRQDAETGDVILSRKPANWDGFLAALKGAAVPAGFLGKNERKQAAHDRDP
FKDWAE

Nucleotide

• Length: 261 bp

>AT30563 NZ_AP012547:131330-131590 [Sulfuritalea hydrogenivorans sk43H]
ATGAGCCAGGTCGCCAAACTATTCACCAATGGTCGCAGCCAGGCGGTTCGCCTGCCCGCCGCCTATCGCTTCGATACCAG
CGAAGTCTTCATTCGCCAGGACGCCGAAACCGGCGACGTGATCCTGTCGCGCAAGCCGGCGAACTGGGATGGTTTCCTTG
CGGCGCTCAAGGGCGCTGCCGTGCCTGCCGGCTTTCTCGGCAAGAACGAGCGCAAGCAGGCGGCGCATGACCGTGATCCC
TTCAAGGACTGGGCCGAGTGA

Structures

Antitoxin

• AlphaFold DB: W0SAN8