Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1580143..1580755 Replicon chromosome
Accession NZ_AP012335
Organism Streptococcus pyogenes JRS4

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag SPYJRS4_RS07895 Protein ID WP_011018227.1
Coordinates 1580420..1580755 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag SPYJRS4_RS07890 Protein ID WP_002988079.1
Coordinates 1580143..1580430 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPYJRS4_RS07865 1575334..1576317 - 984 WP_011184964.1 tagatose-bisphosphate aldolase -
SPYJRS4_RS07870 1576321..1577250 - 930 WP_011184965.1 tagatose-6-phosphate kinase -
SPYJRS4_RS07875 1577296..1577811 - 516 WP_011184966.1 galactose-6-phosphate isomerase subunit LacB -
SPYJRS4_RS07880 1577846..1578274 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
SPYJRS4_RS07885 1578720..1579493 + 774 WP_011184967.1 DeoR/GlpR family DNA-binding transcription regulator -
SPYJRS4_RS07890 1580143..1580430 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
SPYJRS4_RS07895 1580420..1580755 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SPYJRS4_RS09550 1580853..1581891 + 1039 Protein_1510 site-specific integrase -
SPYJRS4_RS07905 1582023..1582415 - 393 WP_002982716.1 30S ribosomal protein S9 -
SPYJRS4_RS07910 1582436..1582882 - 447 WP_011018228.1 50S ribosomal protein L13 -
SPYJRS4_RS07915 1583100..1583306 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
SPYJRS4_RS07920 1583303..1584001 - 699 WP_021340263.1 hypothetical protein -
SPYJRS4_RS07925 1584137..1584997 - 861 WP_002982687.1 DegV family protein -
SPYJRS4_RS07930 1585094..1585612 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T30550 WP_011018227.1 NZ_AP012335:1580420-1580755 [Streptococcus pyogenes JRS4]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T30550 NZ_AP012335:1580420-1580755 [Streptococcus pyogenes JRS4]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT30550 WP_002988079.1 NZ_AP012335:1580143-1580430 [Streptococcus pyogenes JRS4]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT30550 NZ_AP012335:1580143-1580430 [Streptococcus pyogenes JRS4]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAACAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References