Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 888595..889190 Replicon chromosome
Accession NZ_AP012273
Organism Thiolapillus brandeum strain Hiromi

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U6JI06
Locus tag TBH_RS04195 Protein ID WP_041065786.1
Coordinates 888936..889190 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7U6JGP2
Locus tag TBH_RS04190 Protein ID WP_041065784.1
Coordinates 888595..888939 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBH_RS04165 885147..885440 - 294 WP_041065770.1 type II toxin-antitoxin system RelE/ParE family toxin -
TBH_RS04170 885434..885613 - 180 WP_041065773.1 hypothetical protein -
TBH_RS15620 885919..887139 - 1221 WP_041065777.1 integrase core domain-containing protein -
TBH_RS04180 887150..887656 - 507 WP_041065781.1 transposase -
TBH_RS04185 887696..888427 - 732 WP_082030575.1 transposase -
TBH_RS04190 888595..888939 - 345 WP_041065784.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
TBH_RS04195 888936..889190 - 255 WP_041065786.1 type II toxin-antitoxin system HicA family toxin Toxin
TBH_RS04200 889456..889980 - 525 WP_041065789.1 iron transporter -
TBH_RS04205 890186..890689 - 504 WP_041065792.1 non-heme ferritin -
TBH_RS04210 890950..892155 - 1206 WP_041065795.1 DUF2325 domain-containing protein -
TBH_RS04215 892158..893624 - 1467 WP_052469866.1 4Fe-4S binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(57-106)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9586.99 Da        Isoelectric Point: 10.5538

>T30535 WP_041065786.1 NZ_AP012273:c889190-888936 [Thiolapillus brandeum]
MKKKHQKTLARLFSRPTSGTIAWREIEALFVELGAEISEREGSRVGVYLFDEIRVFHRPHPSPETDKGAVASIRTWLQQN
GVKP

Download         Length: 255 bp

>T30535 NZ_AP012273:c889190-888936 [Thiolapillus brandeum]
ATGAAAAAGAAGCACCAAAAGACACTGGCCCGCCTGTTTTCCCGTCCGACCAGTGGCACGATTGCCTGGCGGGAGATTGA
GGCCCTGTTTGTGGAGCTTGGAGCAGAGATCAGCGAGCGGGAAGGCTCCCGTGTCGGGGTGTATTTGTTTGATGAAATCC
GGGTCTTTCACCGTCCCCACCCATCACCGGAGACAGATAAAGGCGCGGTGGCCAGCATACGAACCTGGCTGCAACAAAAT
GGGGTGAAGCCATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13082.80 Da        Isoelectric Point: 6.0916

>AT30535 WP_041065784.1 NZ_AP012273:c888939-888595 [Thiolapillus brandeum]
MKQNLMEIDGYHALISYDPEIEMFRGEFVDLNGGADFYARDIENLRREGQVSLNVFMDMCREKGIDPKRRFSGRFNVRIP
SDLHARIARTAKAQGKSLNQLVAEALEHEVSEAH

Download         Length: 345 bp

>AT30535 NZ_AP012273:c888939-888595 [Thiolapillus brandeum]
ATGAAGCAAAATCTGATGGAAATTGACGGATACCATGCGCTTATCAGCTATGATCCCGAGATAGAGATGTTTCGGGGTGA
GTTCGTGGATCTCAATGGCGGTGCGGATTTTTACGCACGAGACATTGAAAATCTACGTCGTGAAGGCCAGGTCTCGCTGA
ACGTGTTTATGGATATGTGTCGGGAAAAGGGCATTGATCCCAAACGCCGGTTTTCCGGTCGGTTCAATGTTCGTATCCCC
AGCGATCTGCATGCACGTATCGCTCGCACTGCAAAAGCACAGGGCAAGAGCCTGAATCAGCTTGTCGCCGAGGCCCTGGA
ACATGAGGTGAGCGAAGCTCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U6JI06

Antitoxin

Source ID Structure
AlphaFold DB A0A7U6JGP2

References