Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 638359..638900 Replicon chromosome
Accession NZ_AP012273
Organism Thiolapillus brandeum strain Hiromi

Toxin (Protein)


Gene name parE Uniprot ID A0A7U6GH57
Locus tag TBH_RS03110 Protein ID WP_041065365.1
Coordinates 638598..638900 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7U6GH38
Locus tag TBH_RS03105 Protein ID WP_041065362.1
Coordinates 638359..638598 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBH_RS03085 634471..636156 + 1686 WP_144375164.1 hypothetical protein -
TBH_RS03090 636181..636510 - 330 WP_041065353.1 transposase -
TBH_RS03100 636572..638144 + 1573 Protein_610 IS3 family transposase -
TBH_RS15605 638198..638299 + 102 WP_172649451.1 integrase core domain-containing protein -
TBH_RS03105 638359..638598 + 240 WP_041065362.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
TBH_RS03110 638598..638900 + 303 WP_041065365.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TBH_RS15850 639214..639366 + 153 WP_144375167.1 IS110 family transposase -
TBH_RS03115 639433..640698 + 1266 WP_041065368.1 IS256 family transposase -
TBH_RS03120 641188..642351 - 1164 WP_041065371.1 ribonucleotide-diphosphate reductase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(4-71)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11464.13 Da        Isoelectric Point: 8.9224

>T30534 WP_041065365.1 NZ_AP012273:638598-638900 [Thiolapillus brandeum]
MGAFSLTHAAKNDLRGIARFTEERWGRAQRRHYLKGLDEAFKMLADSPKLGNSCDYIEPGLRKYPFQSHVVFYDLLSDEA
IQVVRVLHKSMDVHQAVFPA

Download         Length: 303 bp

>T30534 NZ_AP012273:638598-638900 [Thiolapillus brandeum]
ATGGGTGCATTTTCTCTTACCCATGCAGCTAAGAATGATTTGCGCGGAATTGCCCGTTTCACCGAAGAACGCTGGGGACG
CGCACAGCGCAGGCATTATCTGAAAGGATTGGACGAGGCTTTCAAAATGCTGGCTGATTCCCCCAAACTGGGAAATTCCT
GCGATTACATTGAGCCAGGCCTTCGCAAGTACCCTTTCCAAAGCCACGTAGTTTTTTACGACCTTCTCTCCGATGAAGCG
ATTCAAGTGGTCCGTGTTCTTCACAAAAGCATGGATGTTCATCAGGCCGTCTTCCCCGCCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8845.78 Da        Isoelectric Point: 4.3085

>AT30534 WP_041065362.1 NZ_AP012273:638359-638598 [Thiolapillus brandeum]
MAKNTSVSLGDHFDQFIATQLSTGRYGSATEIVRAGLRLLENEEQKLETLRQLIAEGRASGTAEYSYETFMDELDKDLN

Download         Length: 240 bp

>AT30534 NZ_AP012273:638359-638598 [Thiolapillus brandeum]
ATGGCGAAAAACACCAGTGTGAGCTTGGGAGACCACTTCGACCAGTTTATTGCCACCCAACTTTCGACGGGGCGCTACGG
TTCTGCCACAGAGATAGTGCGAGCAGGATTGCGCCTTCTTGAGAACGAAGAGCAGAAACTGGAAACACTGCGCCAGTTGA
TTGCAGAAGGCCGCGCCAGCGGGACGGCTGAGTACAGCTACGAAACGTTTATGGATGAACTCGATAAAGACCTGAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U6GH57

Antitoxin

Source ID Structure
AlphaFold DB A0A7U6GH38

References