30507

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2187758..2188302 Replicon chromosome
Accession NZ_AM412059
Organism Mycobacterium tuberculosis variant bovis BCG str. Moreau RDJ isolate SL21 FAP RJ Passage B8S2 vaccine culture

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag H056_RS10150 Protein ID WP_003409896.1
Coordinates 2187758..2188054 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag H056_RS10155 Protein ID WP_003409899.1
Coordinates 2188051..2188302 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H056_RS10095 2182791..2183141 - 351 WP_003409871.1 hypothetical protein -
H056_RS10100 2183152..2184054 - 903 WP_003409874.1 hypothetical protein -
H056_RS10105 2184075..2184266 - 192 WP_003409876.1 hypothetical protein -
H056_RS10110 2184267..2184563 - 297 WP_003409877.1 hypothetical protein -
H056_RS10115 2184803..2185018 + 216 WP_003409878.1 antitoxin -
H056_RS10120 2185015..2185326 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
H056_RS21935 2185300..2185821 - 522 WP_010950637.1 hypothetical protein -
H056_RS10130 2185796..2186173 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
H056_RS10135 2186215..2186664 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
H056_RS10140 2186661..2187206 + 546 WP_046026284.1 hypothetical protein -
H056_RS10145 2187095..2187709 - 615 WP_003901296.1 hypothetical protein -
H056_RS10150 2187758..2188054 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H056_RS10155 2188051..2188302 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
H056_RS10160 2188289..2188783 + 495 WP_003899099.1 hypothetical protein -
H056_RS10165 2188943..2189350 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
H056_RS10170 2189354..2189626 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
H056_RS10175 2189659..2190879 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
H056_RS10185 2191778..2192083 + 306 Protein_1991 ABC transporter permease -
H056_RS10190 2192267..2193115 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T30507 WP_003409896.1 NZ_AM412059:c2188054-2187758 [Mycobacterium tuberculosis variant bovis BCG str. Moreau RDJ]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T30507 NZ_AM412059:c2188054-2187758 [Mycobacterium tuberculosis variant bovis BCG str. Moreau RDJ]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT30507 WP_003409899.1 NZ_AM412059:c2188302-2188051 [Mycobacterium tuberculosis variant bovis BCG str. Moreau RDJ]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT30507 NZ_AM412059:c2188302-2188051 [Mycobacterium tuberculosis variant bovis BCG str. Moreau RDJ]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References