Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 445361..446372 Replicon chromosome
Accession NZ_AM412059
Organism Mycobacterium tuberculosis variant bovis BCG str. Moreau RDJ isolate SL21 FAP RJ Passage B8S2 vaccine culture

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag H056_RS01905 Protein ID WP_003401859.1
Coordinates 445361..445954 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag H056_RS01910 Protein ID WP_003401860.1
Coordinates 445983..446372 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H056_RS01885 441010..442392 + 1383 WP_003898415.1 magnesium transporter -
H056_RS01890 442404..443438 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
H056_RS01895 443534..444217 + 684 WP_010950388.1 VTT domain-containing protein -
H056_RS01900 444206..445336 - 1131 WP_003401858.1 hypothetical protein -
H056_RS01905 445361..445954 - 594 WP_003401859.1 zeta toxin family protein Toxin
H056_RS01910 445983..446372 - 390 WP_003401860.1 hypothetical protein Antitoxin
H056_RS01915 446453..447664 - 1212 WP_003401861.1 VWA domain-containing protein -
H056_RS01920 447670..448272 - 603 WP_003898417.1 SRPBCC family protein -
H056_RS01925 448286..449182 - 897 WP_003401863.1 MoxR family ATPase -
H056_RS01930 449179..449772 - 594 WP_003401864.1 NTP transferase domain-containing protein -
H056_RS01935 449769..450524 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T30479 WP_003401859.1 NZ_AM412059:c445954-445361 [Mycobacterium tuberculosis variant bovis BCG str. Moreau RDJ]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T30479 NZ_AM412059:c445954-445361 [Mycobacterium tuberculosis variant bovis BCG str. Moreau RDJ]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT30479 WP_003401860.1 NZ_AM412059:c446372-445983 [Mycobacterium tuberculosis variant bovis BCG str. Moreau RDJ]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT30479 NZ_AM412059:c446372-445983 [Mycobacterium tuberculosis variant bovis BCG str. Moreau RDJ]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References