30444

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 3477415..3477914 Replicon chromosome
Accession NC_023150
Organism Rhodococcus pyridinivorans SB3094

Toxin (Protein)


Gene name relE Uniprot ID V9XF56
Locus tag Y013_RS15725 Protein ID WP_024102500.1
Coordinates 3477415..3477669 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID H0JMW3
Locus tag Y013_RS15730 Protein ID WP_006550855.1
Coordinates 3477666..3477914 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y013_RS15695 3472621..3473859 + 1239 WP_024102494.1 helix-turn-helix domain-containing protein -
Y013_RS26875 3473928..3474735 + 808 Protein_3144 IS5 family transposase -
Y013_RS15705 3474906..3475118 - 213 WP_024102496.1 transposase -
Y013_RS15710 3475130..3475366 - 237 WP_080678512.1 transposase -
Y013_RS15715 3475680..3476636 - 957 WP_019290518.1 Lsr2 family protein -
Y013_RS27460 3476793..3477314 + 522 WP_024102499.1 hypothetical protein -
Y013_RS15725 3477415..3477669 - 255 WP_024102500.1 Txe/YoeB family addiction module toxin Toxin
Y013_RS15730 3477666..3477914 - 249 WP_006550855.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Y013_RS15735 3477950..3478279 + 330 WP_080678513.1 hypothetical protein -
Y013_RS15740 3478746..3479540 + 795 WP_006550857.1 LLM class F420-dependent oxidoreductase -
Y013_RS15745 3479601..3480851 + 1251 WP_024102501.1 alpha/beta fold hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10077.42 Da        Isoelectric Point: 8.0410

>T30444 WP_024102500.1 NC_023150:c3477669-3477415 [Rhodococcus pyridinivorans SB3094]
VNITFTDEAWDDYQFWISTDRKQLKRVNELIRDCQRDPYSGIGKPERLRHALSGLWSRRIDKEHRLVYEVIDGALVIIAA
RYHY

Download         Length: 255 bp

>T30444 NC_023150:c3477669-3477415 [Rhodococcus pyridinivorans SB3094]
GTGAACATCACCTTCACCGACGAAGCCTGGGACGACTACCAGTTCTGGATCTCGACCGACAGAAAACAGCTCAAGCGTGT
CAACGAGCTGATCAGGGATTGCCAACGAGACCCGTACTCGGGGATCGGCAAACCCGAACGGCTCAGACATGCCCTGTCAG
GACTGTGGTCTCGACGTATCGACAAAGAACACCGCCTGGTCTACGAGGTCATCGACGGTGCCCTGGTCATCATCGCCGCC
CGCTACCACTACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.59 Da        Isoelectric Point: 5.8315

>AT30444 WP_006550855.1 NC_023150:c3477914-3477666 [Rhodococcus pyridinivorans SB3094]
MAAITATEARKNFFPLLEQVNKDHTPVEIVSKRGNAVLMSKDDYDAMLETSYLMQSPANARRLLASMQRARGGEYTEREL
IE

Download         Length: 249 bp

>AT30444 NC_023150:c3477914-3477666 [Rhodococcus pyridinivorans SB3094]
ATGGCTGCCATCACTGCTACCGAAGCGAGAAAAAACTTCTTTCCGCTGCTCGAACAGGTCAACAAGGACCACACCCCTGT
GGAAATCGTATCCAAGCGGGGCAATGCCGTCCTGATGTCGAAGGATGACTACGACGCCATGCTCGAGACCTCGTACCTGA
TGCAGTCTCCGGCCAACGCCCGACGACTGCTCGCCAGCATGCAGAGAGCTCGCGGAGGTGAATACACCGAAAGGGAACTC
ATCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7M2XPP3

Antitoxin

Source ID Structure
AlphaFold DB H0JMW3

References