Detailed information of TA system TA030443

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 901411..902363
• Replicon: chromosome
• Accession: NC_023150
• Organism: Rhodococcus pyridinivorans SB3094

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: V9XD75
• Locus tag: Y013_RS04130
• Protein ID: WP_024101065.1
• Coordinates: 901411..901980 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: V9X925
• Locus tag: Y013_RS04135
• Protein ID: WP_024101066.1
• Coordinates: 901977..902363 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Y013_RS04130	901411..901980	-	570	WP_024101065.1	zeta toxin family protein	Toxin
Y013_RS04135	901977..902363	-	387	WP_024101066.1	hypothetical protein	Antitoxin
Y013_RS04140	902570..903640	+	1071	WP_041803373.1	class I SAM-dependent methyltransferase	-
Y013_RS04145	903710..904075	+	366	WP_024101068.1	HNH endonuclease	-
Y013_RS04150	904092..904637	-	546	WP_041803375.1	hypothetical protein	-
Y013_RS04155	905751..906683	-	933	WP_024101070.1	TAXI family TRAP transporter solute-binding subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-102)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 20524.65 Da
• Isoelectric Point: 10.6895

>T30443 WP_024101065.1 NC_023150:c901980-901411 [Rhodococcus pyridinivorans SB3094]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEVGFTVVLHAMLVPEAMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVTEAIGRADQASVYDTASGTP
VVVARFAGGVPVGAVRWPGWAPAALTGLG

Nucleotide

• Length: 570 bp

>T30443 NC_023150:c901980-901411 [Rhodococcus pyridinivorans SB3094]
ATGAGGCGTCTGGATCTGATCGTCGGTCCCAACGGTTCCGGCAAGTCGACGTTCGTCGAGTTGTCCCTCGCTCCCCTGCT
GCCGCGCAGCGTGTTCGTCAATGCGGATGTGATCGCGCGGCAGCGCTGGCCCGACCGGGCGGAGGAGATGTCGTACGAGG
CGGCGCAGCTCGCCGCGGCGGCGCGGGACCGGTTGCTGCGGCAGGGCCGGTCGTTCATTGCAGAGACGGTGTTCTCGCAT
CCGTCGAAGCTGGAGTTGATCGACCGCGCGCACGAGGTGGGGTTCACGGTGGTGCTGCACGCGATGCTGGTGCCCGAGGC
GATGTCGGTGCTGCGTGTACAGCACCGGGTGGCCTCCGGTGGGCATGCGGTGCCCGAGGACAAGATCCGGGCGCGCTATC
GGCGGTTGTGGCCGCTGGTGACCGAAGCGATCGGCCGCGCCGATCAGGCGTCGGTGTACGACACGGCGTCCGGGACCCCG
GTGGTGGTGGCGCGGTTCGCCGGCGGGGTGCCGGTGGGTGCGGTGCGCTGGCCGGGATGGGCGCCGGCGGCGCTCACCGG
GCTCGGCTGA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 13980.46 Da
• Isoelectric Point: 4.8349

>AT30443 WP_024101066.1 NC_023150:c902363-901977 [Rhodococcus pyridinivorans SB3094]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DARLAGGLARTDYAEVLAARGVTTVVLDDEGRLVEQRPDGSRRVLDDA

Nucleotide

• Length: 387 bp

>AT30443 NC_023150:c902363-901977 [Rhodococcus pyridinivorans SB3094]
ATGACGTCATCCACCGACAAGGTCACCCGCTTCGACGCCGAACTCGTCGACAGCGCCATCGCCGAGGGCGGCCGCCAGAA
CCGCACTGGACGCCAGCAACTCGAATACTGGGCCCGCATCGGCCGCGCGATGACCGCCCACGAGACCGCCTCCCTGCACC
GGGTGCACGAGGCGCTGGCCGGGACACGGGAGCTGAGCGAGCTCACCGCCGCCGAGGGACGGCTGTTCGACGCGGAGATC
GATGCGCGCCTGGCGGGCGGGCTGGCCCGCACCGACTACGCCGAGGTTCTCGCCGCGCGTGGGGTCACCACGGTGGTGCT
CGACGACGAAGGCCGGCTGGTCGAGCAGCGTCCCGACGGTAGTCGCCGGGTGCTCGACGACGCATGA

Structures

Toxin

• AlphaFold DB: V9XD75

Antitoxin

• AlphaFold DB: V9X925