Detailed information of TA system TA030433

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 201222..201775
• Replicon: plasmid unnamed
• Accession: NC_023144
• Organism: Rhodococcus pyridinivorans SB3094

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V9XQ39
• Locus tag: Y013_RS24815
• Protein ID: WP_024100345.1
• Coordinates: 201494..201775 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V9XPX1
• Locus tag: Y013_RS24810
• Protein ID: WP_024100344.1
• Coordinates: 201222..201497 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Y013_RS24780	196677..196967	-	291	WP_012476944.1	hypothetical protein	-
Y013_RS24785	197040..198076	-	1037	Protein_189	DUF3560 domain-containing protein	-
Y013_RS24790	198135..198722	-	588	WP_024100341.1	hypothetical protein	-
Y013_RS24795	198915..199175	+	261	WP_024100342.1	hypothetical protein	-
Y013_RS27045	199233..199479	+	247	Protein_192	hypothetical protein	-
Y013_RS24800	199538..200821	+	1284	WP_024100303.1	IS256 family transposase	-
Y013_RS24810	201222..201497	+	276	WP_024100344.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
Y013_RS24815	201494..201775	+	282	WP_024100345.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Y013_RS24820	202400..203077	+	678	Protein_196	hypothetical protein	-
Y013_RS24825	203190..204434	-	1245	WP_024100349.1	IS256 family transposase	-
Y013_RS24835	205275..205874	+	600	WP_024100352.1	hypothetical protein	-
Y013_RS24840	205882..206526	+	645	WP_024100353.1	RES family NAD+ phosphorylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..361397	361397
	-	flank	IS/Tn	-	-	203190..204434	1244

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (16-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-73)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10554.14 Da
• Isoelectric Point: 10.2269

>T30433 WP_024100345.1 NC_023144:201494-201775 [Rhodococcus pyridinivorans SB3094]
MTDEAPALYDVAIASPARRSLSRLPGRIVHAVVEFISGPLAENPHRLSKPLRNDLAGLRSARRGDYRILLRVDEEHRTIL
IVDIDHRAHIYRP

Nucleotide

• Length: 282 bp

>T30433 NC_023144:201494-201775 [Rhodococcus pyridinivorans SB3094]
ATGACCGATGAGGCGCCGGCACTCTACGACGTCGCGATCGCCTCACCTGCCCGCCGATCCCTGTCCCGGCTGCCGGGACG
GATCGTGCATGCGGTCGTCGAATTCATCTCCGGCCCACTGGCGGAGAATCCCCACCGGCTGAGCAAACCGCTGCGCAACG
ATCTCGCCGGCCTCCGCAGCGCCCGCCGCGGCGACTACCGCATCCTGCTCCGGGTCGACGAAGAGCACCGCACCATCCTC
ATCGTCGACATCGACCACCGCGCCCACATCTACCGACCCTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9716.82 Da
• Isoelectric Point: 4.8163

>AT30433 WP_024100344.1 NC_023144:201222-201497 [Rhodococcus pyridinivorans SB3094]
VTTVPLGEAKDKLSALVDSAEATHDIITITRHGKPAAVLMSADDLESLHETIYWLSRPGTAESVAAADREYAAGHTASLD
ELRTEHGLPPR

Nucleotide

• Length: 276 bp

>AT30433 NC_023144:201222-201497 [Rhodococcus pyridinivorans SB3094]
GTGACGACGGTACCGCTCGGCGAAGCCAAGGACAAGCTCTCGGCGCTGGTAGACAGTGCCGAAGCCACGCACGACATCAT
CACGATCACCCGGCACGGCAAACCGGCTGCGGTCCTGATGTCGGCCGACGATCTGGAATCACTGCACGAGACGATCTACT
GGCTGTCTCGGCCCGGCACCGCCGAGTCGGTCGCGGCCGCCGACCGCGAGTACGCCGCAGGCCATACCGCCTCGCTCGAC
GAGCTGCGGACCGAGCACGGCCTGCCGCCCCGATGA

Structures

Toxin

• AlphaFold DB: V9XQ39

Antitoxin

• AlphaFold DB: V9XPX1