Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142428..142933 Replicon chromosome
Accession NC_023066
Organism Pseudomonas aeruginosa LES431

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag T223_RS00630 Protein ID WP_003083773.1
Coordinates 142428..142709 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag T223_RS00635 Protein ID WP_003083775.1
Coordinates 142706..142933 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
T223_RS00605 137679..139028 + 1350 WP_012613447.1 C4-dicarboxylate transporter DctA -
T223_RS00610 139077..139763 + 687 WP_003083762.1 FadR family transcriptional regulator -
T223_RS00615 139864..140598 + 735 WP_003117208.1 GntR family transcriptional regulator -
T223_RS00620 140802..141188 + 387 WP_014602345.1 aegerolysin family protein -
T223_RS00625 141220..142128 - 909 WP_012613448.1 LysR family transcriptional regulator -
T223_RS00630 142428..142709 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
T223_RS00635 142706..142933 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
T223_RS00640 143109..143729 - 621 WP_003101226.1 hypothetical protein -
T223_RS00645 143830..144330 + 501 WP_003101228.1 LEA type 2 family protein -
T223_RS00650 144403..144744 + 342 WP_003101229.1 alkylphosphonate utilization protein -
T223_RS00655 144826..146253 - 1428 WP_003083784.1 GABA permease -
T223_RS00660 146422..147915 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T30419 WP_003083773.1 NC_023066:c142709-142428 [Pseudomonas aeruginosa LES431]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T30419 NC_023066:c142709-142428 [Pseudomonas aeruginosa LES431]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT30419 WP_003083775.1 NC_023066:c142933-142706 [Pseudomonas aeruginosa LES431]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT30419 NC_023066:c142933-142706 [Pseudomonas aeruginosa LES431]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References