Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 4306572..4307179 Replicon chromosome
Accession NC_023064
Organism Pseudomonas sp. TKP

Toxin (Protein)


Gene name hicA Uniprot ID A0A855JTJ8
Locus tag U771_RS19030 Protein ID WP_024076056.1
Coordinates 4306572..4306823 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A855JUN5
Locus tag U771_RS19035 Protein ID WP_024076057.1
Coordinates 4306820..4307179 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
U771_RS19030 4306572..4306823 + 252 WP_024076056.1 type II toxin-antitoxin system HicA family toxin Toxin
U771_RS19035 4306820..4307179 + 360 WP_024076057.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
U771_RS19040 4307180..4308352 - 1173 WP_024076058.1 MFS transporter -
U771_RS19045 4308393..4309748 - 1356 WP_024076059.1 MATE family efflux transporter -
U771_RS19050 4309775..4310347 - 573 WP_024076060.1 DUF2239 family protein -
U771_RS19055 4310710..4311057 - 348 WP_024076061.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9562.13 Da        Isoelectric Point: 10.0941

>T30409 WP_024076056.1 NC_023064:4306572-4306823 [Pseudomonas sp. TKP]
VSKNEKLLAKLLNEHMTFTWPELVTLLRRLGYTQIEGAGSRVKFDIGDPTAMITLHKPHPGNELKHYIRRQVIEQLRSGD
LIQ

Download         Length: 252 bp

>T30409 NC_023064:4306572-4306823 [Pseudomonas sp. TKP]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACTGCTCAATGAACACATGACATTCACCTGGCCCGAGCTCGTCACGCTGCT
GCGTCGGCTTGGCTACACACAAATCGAGGGGGCGGGAAGCCGCGTCAAGTTCGACATCGGCGACCCCACGGCAATGATCA
CCTTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGTCGCCAGGTCATCGAACAATTGAGATCAGGAGAC
CTGATTCAGTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 12947.70 Da        Isoelectric Point: 6.4717

>AT30409 WP_024076057.1 NC_023064:4306820-4307179 [Pseudomonas sp. TKP]
VNNQLKYNGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFREAVDDYLATCQTLGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHGADPAIG

Download         Length: 360 bp

>AT30409 NC_023064:4306820-4307179 [Pseudomonas sp. TKP]
GTGAACAACCAACTGAAATACAACGGCTACATCGGCTCTATCGAAGCCAGCCTCGAAGACAACTGCCTGTTCGGCAAAAT
CCTCTTCATCAAGGCGCTGGTCAGCTATGAAGGGAAAACCGTCGCCGAGTTGGACGCGGCCTTCCGCGAGGCCGTGGATG
ACTATCTCGCGACCTGCCAGACCCTGGGGCAAACCCCGGAGAAGCCATGCAAAGGCTCGTTCAATGTGCGGGTCGGCCAT
GACCTGCACCTGGCCGCGGCCCTGGCGGCAACCCGTAAGAAAGTCACGCTCAACGACCTGACGCGCCAGGCGTTGAACGA
GTTCCTGCAACACCACGGCGCAGACCCGGCGATCGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855JTJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A855JUN5

References