30408

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 772643..773236 Replicon chromosome
Accession NC_023064
Organism Pseudomonas sp. TKP

Toxin (Protein)


Gene name relE Uniprot ID A0A855JZ99
Locus tag U771_RS03360 Protein ID WP_024073151.1
Coordinates 772934..773236 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A855JY32
Locus tag U771_RS03355 Protein ID WP_024073150.1
Coordinates 772643..772930 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
U771_RS03335 769045..771114 - 2070 WP_024073146.1 TonB-dependent copper receptor -
U771_RS03340 771207..771608 - 402 WP_024073147.1 DUF2946 domain-containing protein -
U771_RS03345 771620..772102 - 483 WP_024073148.1 copper chaperone PCu(A)C -
U771_RS03350 772150..772545 - 396 WP_024073149.1 DUF2946 domain-containing protein -
U771_RS03355 772643..772930 - 288 WP_024073150.1 putative addiction module antidote protein Antitoxin
U771_RS03360 772934..773236 - 303 WP_024073151.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
U771_RS03365 773754..774008 + 255 WP_024073152.1 hypothetical protein -
U771_RS03370 774052..774375 - 324 WP_024073153.1 transcriptional regulator -
U771_RS03375 774381..774713 - 333 WP_024073154.1 addiction module protein -
U771_RS03380 774770..775495 - 726 WP_024073155.1 cobalt-precorrin-6A reductase -
U771_RS03385 775492..776697 - 1206 WP_024073156.1 bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase -
U771_RS03390 776820..778082 + 1263 WP_093235746.1 precorrin-3B synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11717.47 Da        Isoelectric Point: 10.1888

>T30408 WP_024073151.1 NC_023064:c773236-772934 [Pseudomonas sp. TKP]
MIQFKKSKHFLEWLDSLRSKPARARVLARLDHAQWGNFGDCEALGNGVFEMRIHYGPGYRVYFTRRGEVVYLLLIGGDKS
TQKRDIQRAKQIAEDFEKKE

Download         Length: 303 bp

>T30408 NC_023064:c773236-772934 [Pseudomonas sp. TKP]
ATGATTCAGTTTAAGAAGTCAAAACACTTTCTAGAATGGCTTGATTCGTTACGCAGTAAACCCGCGCGAGCACGCGTACT
GGCAAGGTTGGATCACGCGCAATGGGGCAACTTTGGAGACTGCGAAGCACTCGGAAATGGCGTTTTTGAAATGCGCATCC
ACTATGGCCCTGGCTACAGGGTTTATTTCACTCGCAGAGGCGAGGTGGTTTACCTGCTGTTGATCGGAGGCGACAAATCA
ACGCAGAAACGTGACATTCAGCGCGCTAAACAAATTGCAGAAGACTTTGAAAAAAAGGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10391.78 Da        Isoelectric Point: 4.4791

>AT30408 WP_024073150.1 NC_023064:c772930-772643 [Pseudomonas sp. TKP]
MNEFTDFDVAEHLKNPEDMAEYLEACFEEDTGDGLLIRSALNNIARAQGMTQVARDAGLGRESLYKALSSNGNPEFATIM
KVMKALGLKLHATAI

Download         Length: 288 bp

>AT30408 NC_023064:c772930-772643 [Pseudomonas sp. TKP]
ATGAATGAATTCACTGACTTCGACGTGGCGGAGCACCTAAAAAACCCCGAGGATATGGCCGAATATCTTGAAGCGTGCTT
CGAAGAAGATACGGGTGACGGTCTGCTGATCCGTTCAGCGCTAAACAACATCGCCCGCGCCCAAGGCATGACCCAAGTAG
CCCGCGATGCCGGCCTCGGAAGAGAAAGTCTATACAAAGCCCTCTCCAGCAATGGCAATCCCGAGTTCGCGACTATCATG
AAAGTCATGAAGGCTTTGGGCCTCAAGCTTCACGCTACAGCGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855JZ99

Antitoxin

Source ID Structure
AlphaFold DB A0A855JY32

References