Detailed information of TA system TA030397

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 2456935..2457542
• Replicon: chromosome
• Accession: NC_023035
• Organism: Salinispira pacifica

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L21SP2_RS10845
• Protein ID: WP_024268549.1
• Coordinates: 2456935..2457324 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: V5WKC8
• Locus tag: L21SP2_RS10850
• Protein ID: WP_024268550.1
• Coordinates: 2457321..2457542 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L21SP2_RS10825	2452975..2454597	-	1623	WP_041401510.1	AAA family ATPase	-
L21SP2_RS10830	2454594..2455220	-	627	WP_024268546.1	DUF4194 domain-containing protein	-
L21SP2_RS10835	2455217..2456668	-	1452	WP_024268547.1	DUF3375 domain-containing protein	-
L21SP2_RS18695	2456756..2456938	-	183	WP_024268548.1	HigA protein (antitoxin to HigB)	-
L21SP2_RS10845	2456935..2457324	-	390	WP_024268549.1	type II toxin-antitoxin system VapC family toxin	Toxin
L21SP2_RS10850	2457321..2457542	-	222	WP_024268550.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
L21SP2_RS10855	2458117..2459931	+	1815	WP_024268551.1	B12-binding domain-containing radical SAM protein	-
L21SP2_RS10860	2459976..2460410	-	435	WP_041401514.1	transcriptional repressor	-
L21SP2_RS10865	2460473..2461612	-	1140	WP_024268553.1	GTP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-54)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14769.74 Da
• Isoelectric Point: 4.8991

>T30397 WP_024268549.1 NC_023035:c2457324-2456935 [Salinispira pacifica]
MSSYLLDTHCLLWWWSAENELSDAVRSLIENPMNTIIVSAASAWEISTKTRIGKLPQGEQIIAQWQKRINEDHFDYLDIS
AEHALKAGMLNGEHRDPFDRMLSAQSLIEGNPLLSKDTKLDQFGISRIW

Nucleotide

• Length: 390 bp

>T30397 NC_023035:c2457324-2456935 [Salinispira pacifica]
ATGAGTAGTTACCTTCTGGATACTCATTGCCTCCTGTGGTGGTGGTCGGCTGAAAACGAACTGAGTGATGCGGTCCGCTC
CCTGATCGAAAACCCCATGAACACCATAATTGTGAGTGCTGCATCTGCCTGGGAGATTTCTACCAAAACACGAATTGGAA
AGTTGCCACAGGGAGAACAAATAATCGCACAATGGCAGAAGCGAATAAACGAAGATCACTTCGACTACCTCGATATCAGC
GCCGAGCATGCCCTGAAAGCGGGCATGCTCAACGGTGAGCATCGAGATCCTTTCGACCGGATGCTCAGCGCCCAATCATT
AATTGAAGGTAATCCCCTCCTCAGCAAAGATACTAAACTGGATCAGTTCGGAATTTCACGGATCTGGTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8181.35 Da
• Isoelectric Point: 5.5675

>AT30397 WP_024268550.1 NC_023035:c2457542-2457321 [Salinispira pacifica]
MEKINVHQAKTHFSAILEKAHNGEVVIIAKAGKPYARLMPLDTQAARTAGRYPMEIPDSFFDELPESELDVWG

Nucleotide

• Length: 222 bp

>AT30397 NC_023035:c2457542-2457321 [Salinispira pacifica]
ATGGAAAAGATAAACGTCCACCAGGCGAAGACTCATTTCTCGGCAATTCTTGAAAAGGCTCATAATGGTGAAGTTGTGAT
CATCGCTAAAGCAGGAAAACCGTATGCGCGCCTCATGCCGCTGGATACGCAGGCGGCGAGAACTGCTGGACGCTACCCTA
TGGAAATCCCCGACAGCTTTTTCGATGAACTTCCTGAATCGGAACTGGATGTCTGGGGATGA

Structures

Antitoxin

• AlphaFold DB: V5WKC8