Detailed information of TA system TA030396

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2221829..2222472
• Replicon: chromosome
• Accession: NC_023035
• Organism: Salinispira pacifica

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L21SP2_RS09865
• Protein ID: WP_041402743.1
• Coordinates: 2221829..2222239 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: V5WI29
• Locus tag: L21SP2_RS09870
• Protein ID: WP_024268322.1
• Coordinates: 2222245..2222472 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L21SP2_RS09850	2218189..2218473	-	285	WP_024268354.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
L21SP2_RS09855	2218603..2219139	-	537	WP_041401460.1	hypothetical protein	-
L21SP2_RS09860	2219396..2220925	-	1530	WP_024268355.1	transposase	-
L21SP2_RS09865	2221829..2222239	-	411	WP_041402743.1	type II toxin-antitoxin system VapC family toxin	Toxin
L21SP2_RS09870	2222245..2222472	-	228	WP_024268322.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
L21SP2_RS09875	2222794..2224323	-	1530	WP_024268355.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2218603..2237487	18884

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-125)

Antitoxin

• SpoVT-AbrB domain (7-49)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15600.88 Da
• Isoelectric Point: 4.1774

>T30396 WP_041402743.1 NC_023035:c2222239-2221829 [Salinispira pacifica]
IYLFDTNICIYLIKNKFPAMLDRIESIGIENIGISTITLAELEFGIANSDPEKLEQNRNALMEFLIPFDIIEFSSTDAFE
YGQIRTHLKNQGILIGNMDMLIGAQARARDLILVTNNEKEFQRIESLEIENWTITN

Nucleotide

• Length: 411 bp

>T30396 NC_023035:c2222239-2221829 [Salinispira pacifica]
ATTTATCTATTCGATACCAATATTTGCATCTATCTAATAAAAAATAAATTTCCGGCGATGCTCGACAGAATTGAATCAAT
CGGAATAGAAAATATTGGAATATCGACAATAACTCTGGCAGAACTTGAATTTGGCATTGCGAACTCAGATCCTGAAAAAC
TAGAACAAAATAGAAATGCCCTCATGGAATTCCTCATTCCATTTGATATTATCGAATTTTCCAGTACAGATGCATTTGAA
TACGGGCAAATTAGAACACACTTAAAAAATCAAGGAATACTTATCGGCAATATGGATATGCTCATTGGTGCTCAGGCGCG
GGCGAGAGATCTTATACTTGTGACAAATAACGAGAAAGAATTTCAAAGGATCGAGTCACTTGAAATCGAGAATTGGACAA
TCACAAATTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8828.10 Da
• Isoelectric Point: 6.3396

>AT30396 WP_024268322.1 NC_023035:c2222472-2222245 [Salinispira pacifica]
VDTAKLFVNGKSQAVRLPKEYRFSGSDVFIKKIDDIVMLIPKDKIWKLFRESFDKFSSELDFTRENDAPQERETL

Nucleotide

• Length: 228 bp

>AT30396 NC_023035:c2222472-2222245 [Salinispira pacifica]
GTGGATACAGCAAAACTCTTTGTGAATGGGAAAAGCCAGGCGGTTCGCTTACCCAAAGAATATCGATTTTCAGGATCCGA
TGTATTTATAAAAAAAATTGATGATATCGTAATGCTCATTCCCAAAGATAAAATCTGGAAACTATTTCGAGAATCATTCG
ATAAATTTTCCTCAGAGCTGGACTTCACTCGTGAAAATGACGCTCCACAGGAACGGGAAACATTGTAG

Structures

Antitoxin

• AlphaFold DB: V5WI29