Detailed information of TA system TA030369

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 4702919..4703475
• Accession: NC_023018
• Organism: Pandoraea sp. RB-44

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: X636_RS21195
• Protein ID: WP_023872356.1
• Coordinates: 4702919..4703209 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: X636_RS21200
• Protein ID: WP_004541313.1
• Coordinates: 4703197..4703475 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
X636_RS21175	4698403..4698924	+	522	WP_004541357.1	hypothetical protein	-
X636_RS21180	4699151..4701352	+	2202	WP_004541389.1	AAA family ATPase	-
X636_RS25150	4701394..4702053	-	660	WP_020850627.1	hypothetical protein	-
X636_RS25085	4702158..4702406	-	249	WP_004541364.1	hypothetical protein	-
X636_RS21190	4702602..4702922	-	321	WP_024429388.1	hypothetical protein	-
X636_RS21195	4702919..4703209	-	291	WP_023872356.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
X636_RS21200	4703197..4703475	-	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
X636_RS21205	4703556..4705577	-	2022	WP_072619152.1	relaxase/mobilization nuclease domain-containing protein	-
X636_RS21210	4705583..4705852	-	270	WP_020850841.1	ribbon-helix-helix protein, CopG family	-
X636_RS21215	4706343..4706600	+	258	WP_004541318.1	hypothetical protein	-
X636_RS21220	4706819..4707636	+	818	Protein_4167	IS5 family transposase	-
X636_RS24485	4707774..4708214	+	441	WP_080685279.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4694056..4746615	52559
	-	flank	IS/Tn	-	-	4706819..4707262	443

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10964.51 Da
• Isoelectric Point: 8.5038

>T30369 WP_023872356.1 NC_023018:c4703209-4702919 [Pandoraea pnomenusa]
MPQVIFAPAAIEDMQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRVDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T30369 NC_023018:c4703209-4702919 [Pandoraea pnomenusa]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGAGGACATGCAACGGCTCCGCGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGTCTCATAG
AAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGTGGCTATGTGGCTCGGTACCGCGTCGATGGC
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCAGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT30369 WP_004541313.1 NC_023018:c4703475-4703197 [Pandoraea pnomenusa]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT30369 NC_023018:c4703475-4703197 [Pandoraea pnomenusa]
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCACTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGTGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0