Detailed information of TA system TA030368

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2170134..2170717
• Accession: NC_023018
• Organism: Pandoraea sp. RB-44

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A9E9DDT9
• Locus tag: X636_RS09935
• Protein ID: WP_010806546.1
• Coordinates: 2170526..2170717 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: X636_RS09930
• Protein ID: WP_023874000.1
• Coordinates: 2170134..2170529 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
X636_RS09895	2165559..2166068	+	510	WP_145929452.1	hypothetical protein	-
X636_RS09900	2166080..2167030	+	951	WP_024788419.1	hypothetical protein	-
X636_RS09905	2166981..2167757	+	777	WP_023873995.1	hypothetical protein	-
X636_RS09910	2167999..2168334	+	336	WP_023873997.1	hypothetical protein	-
X636_RS24680	2168331..2169023	+	693	WP_051399259.1	HNH endonuclease	-
X636_RS09920	2169132..2169758	+	627	WP_023873998.1	hypothetical protein	-
X636_RS09925	2169860..2170111	-	252	WP_023873999.1	hypothetical protein	-
X636_RS09930	2170134..2170529	-	396	WP_023874000.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
X636_RS09935	2170526..2170717	-	192	WP_010806546.1	type II toxin-antitoxin system HicA family toxin	Toxin
X636_RS09940	2171361..2172734	+	1374	WP_023874002.1	ParB N-terminal domain-containing protein	-
X636_RS09945	2172734..2173144	+	411	WP_023874003.1	hypothetical protein	-
X636_RS09950	2173095..2174651	+	1557	WP_023874004.1	phage terminase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2148830..2198688	49858

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-124)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7096.21 Da
• Isoelectric Point: 11.3261

>T30368 WP_010806546.1 NC_023018:c2170717-2170526 [Pandoraea pnomenusa]
MTSADIIKRLKAAGFTEVSVRGSHHKFRHENGRVVIVPHPKKDMPIGTARSIFKQAGIDWRSE

Nucleotide

• Length: 192 bp

>T30368 NC_023018:c2170717-2170526 [Pandoraea pnomenusa]
ATGACAAGCGCAGACATCATCAAACGACTGAAAGCCGCCGGGTTCACCGAAGTGTCGGTGCGCGGCAGCCACCACAAGTT
TCGGCACGAGAACGGTCGAGTGGTGATCGTCCCGCACCCGAAAAAGGACATGCCGATTGGCACCGCCCGCTCGATCTTTA
AGCAAGCGGGCATTGACTGGAGAAGCGAATGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14699.42 Da
• Isoelectric Point: 4.2609

>AT30368 WP_023874000.1 NC_023018:c2170529-2170134 [Pandoraea pnomenusa]
MKYPIYVWQEGDSAFGAAFPDLPGVHTAADTLDDLERNAQEAVELMYEDSDEQIPAPTYDIKKLHANEVDDGTGFWMFVD
IDLSKVSSKAVRLNISLPERLVSQIDAEAEKRHMSRSAFLALAAQREMEHA

Nucleotide

• Length: 396 bp

>AT30368 NC_023018:c2170529-2170134 [Pandoraea pnomenusa]
ATGAAATATCCGATCTACGTGTGGCAGGAAGGCGATAGCGCCTTCGGCGCCGCATTCCCGGATCTGCCGGGGGTGCACAC
CGCTGCGGATACGCTCGACGATCTCGAGCGCAATGCGCAAGAGGCCGTCGAGCTCATGTACGAAGACAGCGACGAGCAGA
TCCCGGCGCCGACATACGACATCAAGAAGCTGCACGCGAATGAAGTGGACGACGGCACCGGCTTCTGGATGTTCGTCGAC
ATTGATCTGTCAAAGGTCAGCAGCAAGGCCGTGCGACTGAACATCAGCCTGCCCGAGCGTCTCGTGAGCCAAATCGATGC
CGAAGCCGAGAAGCGCCATATGTCGCGCTCGGCATTTCTGGCACTCGCGGCACAGCGCGAGATGGAACACGCTTAA