Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1190969..1192835 Replicon
Accession NC_023018
Organism Pandoraea sp. RB-44

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag X636_RS05395 Protein ID WP_023597211.1
Coordinates 1190969..1191895 (+) Length 309 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag X636_RS05400 Protein ID WP_162835271.1
Coordinates 1191897..1192835 (+) Length 313 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
X636_RS05370 1186301..1187377 + 1077 WP_023873350.1 porin -
X636_RS05375 1187787..1188572 + 786 WP_028731111.1 ABC transporter ATP-binding protein -
X636_RS05380 1188613..1189395 + 783 WP_023597214.1 ABC transporter permease -
X636_RS05385 1189412..1190203 + 792 WP_023873352.1 SDR family oxidoreductase -
X636_RS05390 1190262..1190819 + 558 WP_023597212.1 cupin domain-containing protein -
X636_RS05395 1190969..1191895 + 927 WP_023597211.1 alpha/beta fold hydrolase Toxin
X636_RS05400 1191897..1192835 + 939 WP_162835271.1 IclR family transcriptional regulator Antitoxin
X636_RS05405 1192832..1193638 + 807 WP_023597209.1 SDR family oxidoreductase -
X636_RS05410 1193631..1195283 + 1653 WP_023873356.1 thiamine pyrophosphate-binding protein -
X636_RS05415 1195276..1196094 + 819 WP_023873357.1 aspartate dehydrogenase -
X636_RS05420 1196108..1197604 + 1497 WP_023597206.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(59-291)

Antitoxin

Transcription regulator IclR, C-terminal

(167-290)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 31510.61 Da        Isoelectric Point: 6.3804

>T30367 WP_023597211.1 NC_023018:1190969-1191895 [Pandoraea pnomenusa]
MQAQANSSEVSEVSADADVPDVAALRARLAAFPYRTVTTRAGTVGYRCATAQAADAVPVVMLHGIGSGAASWLAQFEATG
LGASLYAWDAPGYGQTTNVAPAEPDADAYADALEAWLDALGLARVAVAGHSLGAIMASRFAARAPHRVLGLFLCSPAGGY
GKADPAVRAAKRDSRLAMLHKLGPAGMARERSDNLVAPNAADLPRAWVKWNMSRVRPEGYAQATHLLSNGDVAGDLARYA
AAKAGPVAVAVGAHDGVTPPASCQAIADVAGVPLQIIEGAGHASYIETPDVLDAALAAWLGRIAAGER

Download         Length: 927 bp

>T30367 NC_023018:1190969-1191895 [Pandoraea pnomenusa]
ATGCAAGCCCAAGCCAACTCGTCCGAAGTGTCCGAAGTGTCCGCAGACGCCGATGTCCCCGATGTCGCCGCCCTGCGCGC
GCGCCTGGCGGCCTTCCCGTATCGCACCGTCACCACGCGCGCGGGGACCGTCGGCTATCGCTGCGCGACGGCGCAAGCCG
CTGATGCCGTCCCTGTGGTGATGCTGCACGGCATCGGGTCGGGGGCGGCGTCGTGGCTGGCGCAGTTCGAAGCGACGGGC
CTTGGCGCCTCGCTTTATGCCTGGGATGCCCCTGGCTACGGTCAGACAACGAATGTCGCGCCTGCCGAGCCGGATGCCGA
CGCCTACGCCGACGCCCTCGAAGCGTGGCTCGATGCGCTCGGTCTTGCGCGCGTGGCGGTGGCCGGCCATTCGCTCGGCG
CGATCATGGCGTCGAGGTTTGCCGCGCGTGCGCCGCACCGCGTGCTCGGCCTGTTTCTGTGCTCGCCGGCAGGGGGCTAC
GGCAAGGCCGACCCGGCAGTCCGGGCGGCCAAGCGCGACAGCCGCCTGGCGATGCTTCACAAACTCGGTCCCGCGGGCAT
GGCGCGCGAACGCAGCGACAACCTCGTGGCACCGAACGCGGCCGACCTGCCGCGCGCCTGGGTGAAGTGGAACATGTCGC
GGGTGCGGCCCGAGGGCTACGCGCAGGCGACCCATCTGCTCTCGAACGGCGATGTGGCGGGCGACCTGGCCCGGTACGCG
GCGGCCAAGGCCGGCCCCGTCGCGGTGGCCGTCGGCGCCCACGATGGCGTCACCCCTCCCGCGAGCTGCCAGGCGATTGC
CGACGTCGCCGGTGTGCCGCTTCAGATTATCGAAGGGGCCGGCCACGCGTCTTACATTGAAACGCCCGACGTGCTCGATG
CCGCGCTTGCCGCGTGGCTCGGGCGCATTGCGGCAGGGGAGCGTTGA

Antitoxin


Download         Length: 313 a.a.        Molecular weight: 33953.70 Da        Isoelectric Point: 6.0582

>AT30367 WP_162835271.1 NC_023018:1191897-1192835 [Pandoraea pnomenusa]
MAPANPKRAVAAASIDDSTQDVQDMQDTLDDEVAEAAPAESRYLVPGLERGLRILTQFSPRESVFSAPELSQRLGIPRTT
VFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQSV
AGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLAELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFERG
ISVVSAPVRNDAGRICAAITVTIPRANIDSAMLDAGLIGQVREAADALSHRLNYRPGGDGRTSPYMKSLGLK

Download         Length: 939 bp

>AT30367 NC_023018:1191897-1192835 [Pandoraea pnomenusa]
ATGGCACCCGCCAATCCGAAACGCGCCGTCGCCGCGGCGTCGATCGACGACAGCACGCAGGACGTACAGGACATGCAGGA
CACGCTGGACGACGAAGTCGCCGAGGCGGCGCCCGCCGAATCGCGTTACCTCGTGCCGGGGCTGGAGCGCGGCCTGCGCA
TCCTGACGCAATTCTCGCCGCGCGAGTCGGTCTTCAGCGCACCGGAGCTCTCGCAGCGCCTCGGTATTCCGCGCACGACG
GTCTTCCGTTTGCTGCAAACGCTTGAGGCGATGGGCTTTCTCGAGCGCGCGGGCAGCGAAAAGAACTTCCGTCTGGGCGT
GGCGGTGCTGCGTCTGGGCTTCGAATACCTGAGCTCGCTGGAGCTCACCGATCTGGGCATTCCCATCATCGAGCGGCTGC
GCGATGCCACCCAGCTGACGTCGCACATCGTGATTCGCGACGGGCGCGACATCGTGTTCGTGGCCAAGGCGCAGAGCGTG
GCCGGGGTGTTCAATTCGATCAAGGTCAACGTCGGTACGCGCTTGCCTGCGCATGCCACGGTCCACGGCCATGTGCTGAT
GGGCGATCTCACGCTCGCCGAACTGCGTGCGCTGTATCCCGAGAAGACGCTGGAGAAATACACGCCGCAGACCCCCGAGA
CGCTCGCCGAGTTGTTCGAGCGCGTGCGCGAGGACGCCGAACGCGGGTATGCCGTCTCGGCCTCGTCCTTCGAGCGCGGC
ATAAGCGTCGTGAGCGCGCCGGTACGCAACGACGCGGGCCGCATCTGCGCCGCGATCACGGTCACGATCCCGCGCGCGAA
CATCGATTCGGCAATGCTCGACGCGGGACTGATCGGGCAGGTGCGCGAAGCCGCCGACGCGCTCTCGCACCGTCTGAATT
ACCGGCCGGGCGGCGACGGCCGCACCTCCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References