Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 774424..775048 Replicon chromosome
Accession NC_022911
Organism Helicobacter pylori BM012S

Toxin (Protein)


Gene name relE Uniprot ID V5NM94
Locus tag U064_RS03930 Protein ID WP_023592055.1
Coordinates 774782..775048 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V5NMW4
Locus tag U064_RS03925 Protein ID WP_023592054.1
Coordinates 774424..774801 (+) Length 126 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
U064_RS03895 769559..769795 + 237 WP_000335461.1 HypC/HybG/HupF family hydrogenase formation chaperone -
U064_RS03900 769813..770925 + 1113 WP_023592052.1 hydrogenase formation protein HypD -
U064_RS08430 770892..771163 + 272 Protein_727 hypothetical protein -
U064_RS03920 771984..774214 + 2231 Protein_728 Hop family adhesin BabA -
U064_RS03925 774424..774801 + 378 WP_023592054.1 hypothetical protein Antitoxin
U064_RS03930 774782..775048 + 267 WP_023592055.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
U064_RS03935 775154..775678 - 525 WP_001135637.1 acyl-CoA thioesterase -
U064_RS03940 775818..776672 + 855 WP_023592056.1 SDR family oxidoreductase -
U064_RS03945 776665..777645 + 981 WP_000921458.1 iron ABC transporter permease -
U064_RS03950 777645..778412 + 768 WP_023592057.1 ABC transporter ATP-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-88)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10332.17 Da        Isoelectric Point: 8.0602

>T30354 WP_023592055.1 NC_022911:774782-775048 [Helicobacter pylori BM012S]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVENDELILLR
LGSHSELF

Download         Length: 267 bp

>T30354 NC_022911:774782-775048 [Helicobacter pylori BM012S]
GTGTTAAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGAAAGAACCGCTAGATCCCCAATTTAAAGATCATGCTTTGAAAGGAAAGTGGA
AACCTTTTAGGGAATGCCATATTAAAGCTGATATTTTGCTTGTGTATTTAGTGGAAAATGATGAGCTGATTTTGTTAAGG
TTAGGCAGTCATAGCGAGTTGTTTTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14715.70 Da        Isoelectric Point: 8.9992

>AT30354 WP_023592054.1 NC_022911:774424-774801 [Helicobacter pylori BM012S]
MPNSSTKKDYTKYSEKQLVNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
GHETPNIQTQQAMRDALNKETDLIVEDFSSYSDERKKALGVKTQP

Download         Length: 378 bp

>AT30354 NC_022911:774424-774801 [Helicobacter pylori BM012S]
ATGCCTAATTCTTCCACCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTGTTAACTTAATCCATCAATTAGAGCG
AAAAATTAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTT
GGGCATGAAACCCCAAACATTCAAACGCAACAAGCCATGAGAGACGCGCTCAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTACAGCGATGAAAGAAAAAAGGCGTTAGGTGTTAAAACTCAACCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V5NM94


Antitoxin

Source ID Structure
AlphaFold DB V5NMW4

References