Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3929925..3931791 Replicon chromosome
Accession NC_022904
Organism Pandoraea pnomenusa 3kgm

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag U875_RS17610 Protein ID WP_023597211.1
Coordinates 3930865..3931791 (-) Length 309 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag U875_RS17605 Protein ID WP_181762441.1
Coordinates 3929925..3930863 (-) Length 313 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
U875_RS17585 3925156..3926652 - 1497 WP_023597206.1 aldehyde dehydrogenase -
U875_RS17590 3926666..3927484 - 819 WP_023597207.1 aspartate dehydrogenase -
U875_RS17595 3927477..3929129 - 1653 WP_023873356.1 thiamine pyrophosphate-binding protein -
U875_RS17600 3929122..3929928 - 807 WP_023597209.1 SDR family oxidoreductase -
U875_RS17605 3929925..3930863 - 939 WP_181762441.1 IclR family transcriptional regulator Antitoxin
U875_RS17610 3930865..3931791 - 927 WP_023597211.1 alpha/beta fold hydrolase Toxin
U875_RS17615 3931941..3932498 - 558 WP_023597212.1 cupin domain-containing protein -
U875_RS17620 3932557..3933348 - 792 WP_023597213.1 SDR family oxidoreductase -
U875_RS17625 3933365..3934147 - 783 WP_023597214.1 ABC transporter permease -
U875_RS17630 3934188..3934973 - 786 WP_029754279.1 ABC transporter ATP-binding protein -
U875_RS17635 3935383..3936459 - 1077 WP_031627377.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(59-291)

Antitoxin

Transcription regulator IclR, N-terminal

(48-96)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 31510.61 Da        Isoelectric Point: 6.3804

>T30350 WP_023597211.1 NC_022904:c3931791-3930865 [Pandoraea pnomenusa 3kgm]
MQAQANSSEVSEVSADADVPDVAALRARLAAFPYRTVTTRAGTVGYRCATAQAADAVPVVMLHGIGSGAASWLAQFEATG
LGASLYAWDAPGYGQTTNVAPAEPDADAYADALEAWLDALGLARVAVAGHSLGAIMASRFAARAPHRVLGLFLCSPAGGY
GKADPAVRAAKRDSRLAMLHKLGPAGMARERSDNLVAPNAADLPRAWVKWNMSRVRPEGYAQATHLLSNGDVAGDLARYA
AAKAGPVAVAVGAHDGVTPPASCQAIADVAGVPLQIIEGAGHASYIETPDVLDAALAAWLGRIAAGER

Download         Length: 927 bp

>T30350 NC_022904:c3931791-3930865 [Pandoraea pnomenusa 3kgm]
ATGCAAGCCCAAGCCAACTCGTCCGAAGTGTCCGAAGTGTCCGCAGACGCCGATGTCCCCGATGTCGCCGCCCTGCGCGC
GCGCCTGGCGGCCTTCCCGTATCGCACCGTCACCACGCGCGCGGGGACCGTCGGCTATCGCTGCGCGACGGCGCAAGCCG
CTGATGCCGTCCCTGTGGTGATGCTGCACGGCATCGGGTCGGGGGCGGCGTCGTGGCTGGCGCAGTTCGAAGCGACGGGC
CTTGGCGCCTCGCTTTATGCCTGGGATGCCCCTGGCTACGGTCAGACAACGAATGTCGCGCCTGCCGAGCCGGATGCCGA
CGCCTACGCCGACGCCCTCGAAGCGTGGCTCGATGCGCTCGGTCTTGCGCGCGTGGCGGTGGCCGGCCATTCGCTCGGCG
CGATCATGGCGTCGAGGTTTGCCGCGCGTGCGCCGCACCGCGTGCTCGGCCTGTTTCTGTGCTCGCCGGCAGGGGGCTAC
GGCAAGGCCGACCCGGCAGTCCGGGCGGCCAAGCGCGACAGCCGCCTGGCGATGCTTCACAAACTCGGTCCCGCGGGCAT
GGCGCGCGAACGCAGCGACAACCTCGTGGCACCGAACGCGGCCGACCTGCCGCGCGCCTGGGTGAAGTGGAACATGTCGC
GGGTGCGGCCCGAGGGCTACGCGCAGGCGACCCATCTGCTCTCGAACGGCGATGTGGCGGGCGACCTGGCCCGGTACGCG
GCGGCCAAGGCCGGCCCCGTCGCGGTGGCCGTCGGCGCCCACGATGGCGTCACCCCTCCCGCGAGCTGCCAGGCGATTGC
CGACGTCGCCGGTGTGCCGCTTCAGATTATCGAAGGGGCCGGCCACGCGTCTTACATTGAAACGCCCGACGTGCTCGATG
CCGCGCTTGCCGCGTGGCTCGGGCGCATTGCGGCAGGGGAGCGTTGA

Antitoxin


Download         Length: 313 a.a.        Molecular weight: 33937.70 Da        Isoelectric Point: 6.0582

>AT30350 WP_181762441.1 NC_022904:c3930863-3929925 [Pandoraea pnomenusa 3kgm]
MAPANPKRAVAAAAIDDSTQDVQDMQDTLDDEVAEAAPAESRYLVPGLERGLRILTQFSPRESVFSAPELSQRLGIPRTT
VFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQSV
AGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLAELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFERG
ISVVSAPVRNDAGRICAAITVTIPRANIDSAMLDAGLIGQVREAADALSHRLNYRPGGDGRTSPYMKSLGLK

Download         Length: 939 bp

>AT30350 NC_022904:c3930863-3929925 [Pandoraea pnomenusa 3kgm]
ATGGCACCCGCCAATCCGAAGCGCGCCGTCGCCGCGGCGGCGATCGACGACAGCACGCAGGACGTACAGGACATGCAGGA
CACGCTGGACGACGAAGTCGCCGAGGCGGCGCCGGCCGAATCGCGTTACCTCGTGCCGGGGCTGGAGCGCGGCCTGCGCA
TCCTGACGCAATTCTCGCCGCGCGAGTCGGTCTTCAGCGCACCGGAGCTCTCGCAGCGCCTCGGTATTCCGCGCACGACG
GTCTTCCGTTTGCTGCAAACGCTTGAGGCGATGGGCTTTCTCGAGCGCGCGGGCAGCGAAAAGAACTTCCGTCTGGGCGT
GGCGGTGCTGCGTCTGGGCTTCGAATACCTGAGCTCGCTGGAGCTCACCGATCTGGGCATTCCCATCATCGAGCGGCTGC
GCGATGCCACCCAGCTGACGTCGCACATCGTGATTCGCGACGGGCGCGACATCGTGTTCGTGGCCAAGGCGCAGAGCGTG
GCCGGGGTGTTCAATTCGATCAAGGTCAACGTCGGTACGCGCTTGCCTGCGCATGCCACGGTCCACGGCCATGTGCTGAT
GGGCGATCTCACGCTCGCCGAACTGCGTGCGCTGTATCCCGAGAAGACGCTGGAGAAATACACGCCGCAGACCCCCGAGA
CGCTCGCCGAGTTGTTCGAGCGCGTGCGCGAGGACGCCGAACGCGGGTATGCCGTCTCGGCCTCGTCCTTCGAGCGCGGC
ATAAGCGTCGTGAGCGCGCCGGTACGCAACGACGCGGGCCGCATCTGCGCCGCGATCACGGTCACGATCCCGCGCGCGAA
CATCGATTCGGCAATGCTCGACGCGGGACTGATCGGGCAGGTGCGCGAAGCCGCCGACGCGCTCTCGCACCGTCTGAATT
ACCGGCCGGGCGGCGACGGCCGCACCTCCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References