Detailed information of TA system TA030348

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 426319..426875
• Replicon: chromosome
• Accession: NC_022904
• Organism: Pandoraea pnomenusa 3kgm

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: U875_RS01950
• Protein ID: WP_023594135.1
• Coordinates: 426585..426875 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: U875_RS01945
• Protein ID: WP_004541313.1
• Coordinates: 426319..426597 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
U875_RS24880	421580..422020	-	441	WP_080685279.1	tyrosine-type recombinase/integrase	-
U875_RS24885	422158..422975	-	818	Protein_371	IS5 family transposase	-
U875_RS24890	423194..423451	-	258	WP_004541318.1	hypothetical protein	-
U875_RS01935	423942..424211	+	270	WP_020850841.1	ribbon-helix-helix protein, CopG family	-
U875_RS01940	424217..426238	+	2022	WP_072619152.1	relaxase/mobilization nuclease domain-containing protein	-
U875_RS01945	426319..426597	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
U875_RS01950	426585..426875	+	291	WP_023594135.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
U875_RS01955	426872..427192	+	321	WP_024429388.1	hypothetical protein	-
U875_RS25955	427388..427636	+	249	WP_004541364.1	hypothetical protein	-
U875_RS25960	427741..428400	+	660	WP_020850627.1	hypothetical protein	-
U875_RS01965	428442..430643	-	2202	WP_004541389.1	AAA family ATPase	-
U875_RS01970	430870..431391	-	522	WP_004541357.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	383346..435738	52392
	-	flank	IS/Tn	-	-	422532..422975	443

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10892.45 Da
• Isoelectric Point: 9.5554

>T30348 WP_023594135.1 NC_022904:426585-426875 [Pandoraea pnomenusa 3kgm]
MPQVIFAPAAIGDMQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRVDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T30348 NC_022904:426585-426875 [Pandoraea pnomenusa 3kgm]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCAACGGCTCCGCGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGTCTCATAG
AAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGTGGCTATGTGGCTCGGTACCGCGTCGATGGC
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCAGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT30348 WP_004541313.1 NC_022904:426319-426597 [Pandoraea pnomenusa 3kgm]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT30348 NC_022904:426319-426597 [Pandoraea pnomenusa 3kgm]
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCACTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGTGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0