30347

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 6310..8033 Replicon plasmid unnamed
Accession NC_022903
Organism Zymomonas mobilis subsp. mobilis str. CP4 = NRRL B-14023

Toxin (Protein)


Gene name pmenT Uniprot ID A0A806D022
Locus tag ZCP4_RS09410 Protein ID WP_012954779.1
Coordinates 7389..8033 (-) Length 215 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID A0A806D8U1
Locus tag ZCP4_RS09405 Protein ID WP_012954778.1
Coordinates 6310..7389 (-) Length 360 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ZCP4_RS09375 1417..1842 - 426 WP_012954797.1 type II toxin-antitoxin system HicB family antitoxin -
ZCP4_RS09775 1852..2049 - 198 WP_012954798.1 type II toxin-antitoxin system HicA family toxin -
ZCP4_RS09380 2244..4013 - 1770 WP_023593790.1 helix-turn-helix domain-containing protein -
ZCP4_RS09385 4120..4371 - 252 WP_011078096.1 DUF2312 domain-containing protein -
ZCP4_RS09390 4496..4813 - 318 WP_012954800.1 hypothetical protein -
ZCP4_RS09400 5275..5736 + 462 WP_025420257.1 hypothetical protein -
ZCP4_RS09405 6310..7389 - 1080 WP_012954778.1 macro domain-containing protein Antitoxin
ZCP4_RS09410 7389..8033 - 645 WP_012954779.1 DUF4433 domain-containing protein Toxin
ZCP4_RS09780 8890..9681 + 792 Protein_8 IS5 family transposase -
ZCP4_RS09425 9939..10739 - 801 WP_012954781.1 Dam family site-specific DNA-(adenine-N6)-methyltransferase -
ZCP4_RS09430 10786..12108 - 1323 WP_012954782.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..30952 30952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-214)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 215 a.a.        Molecular weight: 25002.73 Da        Isoelectric Point: 7.4075

>T30347 WP_012954779.1 NC_022903:c8033-7389 [Zymomonas mobilis subsp. mobilis str. CP4 = NRRL B-14023]
MIYKSFNPQKALIWRIVHYSNLPWILDNGLYCGNSKIKSPNWFNIGNPELIQKRADHSVPLPPSGMLNDYIPFYFTPFSP
MLRNISTGWGGIPQLPNEKIIILVSSLHHIADLGLPFLFTDSHAYSPCANYYSNLSDLNQIDWPILQHRDFKRDPDDPAK
FERYQAEALIYQHLPINGLYGIICYTELLKQRIEQEICARNLNLRVYARPEWYF

Download         Length: 645 bp

>T30347 NC_022903:c8033-7389 [Zymomonas mobilis subsp. mobilis str. CP4 = NRRL B-14023]
ATGATCTATAAAAGTTTTAATCCACAAAAAGCATTGATATGGCGGATTGTCCATTACAGCAATTTGCCATGGATTTTGGA
TAATGGTCTCTACTGTGGCAATAGTAAGATAAAATCACCCAATTGGTTTAATATTGGCAATCCTGAATTAATCCAAAAAC
GCGCTGACCATTCAGTACCACTGCCTCCATCTGGGATGCTGAATGACTATATACCATTTTACTTCACACCATTTTCTCCG
ATGTTACGGAATATTTCGACAGGCTGGGGCGGTATACCCCAATTACCCAATGAGAAAATTATAATTTTGGTATCCAGTCT
TCACCATATTGCTGATCTGGGATTACCCTTTCTTTTTACAGATAGTCATGCCTACTCTCCGTGCGCTAATTATTACTCTA
ACCTATCTGATCTTAACCAGATCGATTGGCCAATATTGCAACATAGAGATTTTAAACGTGACCCAGATGATCCTGCCAAA
TTTGAGCGATATCAGGCTGAAGCACTTATTTACCAGCATTTGCCGATCAACGGACTATATGGCATTATATGTTATACAGA
ATTGTTGAAACAACGCATTGAGCAAGAGATTTGTGCTCGTAATCTCAATCTTCGGGTTTATGCCCGACCGGAATGGTATT
TCTGA

Antitoxin


Download         Length: 360 a.a.        Molecular weight: 40879.22 Da        Isoelectric Point: 9.1190

>AT30347 WP_012954778.1 NC_022903:c7389-6310 [Zymomonas mobilis subsp. mobilis str. CP4 = NRRL B-14023]
MIIFTQGNLLEAKVEALVNTVNTVGVMGKGIALMFKERFHENFRLYSAACKAKEVQIGKMFVTPVYELGETRWIVNFPTK
QHWRNPSRIEWIIKGLQDLRRVLLEKNIKSIAIPPLGAGNGGLSWKDVRGQIELALSDLDIDIFVFEPTSQYQNVAKRTG
VEKLTPARALIAELVRRYWVMGIECSLLEIQKLAWFLQRAIEQYSPDNNPLNLDFQPHKYGPYTHQLNHLLNSLDGSYLH
SDKRISDSDPLDVILFVNKRKDDLQAYLKSEAKPYRQALESAAMLIDGFESPFGMELLATVDWLLTRENIEPNVPALRKG
LRSWRGGEDAALRKDRIFNDRSLGIALDRLTKTSTLAIA

Download         Length: 1080 bp

>AT30347 NC_022903:c7389-6310 [Zymomonas mobilis subsp. mobilis str. CP4 = NRRL B-14023]
ATGATTATCTTCACGCAAGGCAACCTACTAGAAGCTAAAGTCGAGGCTCTTGTTAATACCGTTAACACCGTCGGTGTGAT
GGGTAAGGGTATTGCGCTCATGTTTAAAGAGCGCTTCCACGAGAACTTTCGCCTGTATTCTGCTGCGTGTAAGGCTAAGG
AAGTTCAAATCGGTAAGATGTTCGTTACTCCAGTCTATGAACTAGGGGAAACACGCTGGATTGTGAACTTTCCGACTAAA
CAGCATTGGCGTAATCCGTCACGAATAGAATGGATTATAAAAGGCTTACAGGATCTACGGCGTGTCCTGCTCGAAAAGAA
TATAAAATCTATTGCTATTCCTCCTTTGGGTGCTGGCAATGGCGGGCTTTCATGGAAAGATGTTCGTGGACAGATCGAGT
TGGCCTTAAGTGATCTCGATATTGATATTTTTGTGTTTGAGCCGACTAGCCAATACCAAAACGTGGCTAAGAGGACAGGC
GTAGAAAAACTAACGCCTGCGCGCGCCTTAATAGCTGAATTAGTCCGTCGATACTGGGTAATGGGTATAGAATGCAGTTT
GCTTGAAATTCAAAAGCTGGCTTGGTTTCTTCAGAGAGCTATTGAACAGTATTCTCCAGATAATAATCCACTGAATTTAG
ATTTTCAGCCACATAAATATGGTCCTTATACTCATCAGCTAAACCACTTGTTGAATAGTTTAGATGGCAGCTATCTTCAC
TCTGATAAACGTATCAGCGATAGCGACCCGCTGGATGTCATTTTATTTGTTAATAAGCGCAAAGACGATTTACAGGCTTA
TTTGAAAAGTGAGGCCAAGCCTTATAGGCAAGCGTTAGAATCTGCCGCCATGCTCATTGATGGTTTTGAGTCCCCCTTTG
GGATGGAACTGCTGGCTACAGTTGACTGGCTGCTAACTCGCGAAAATATAGAACCTAATGTGCCAGCTTTACGTAAGGGA
TTGCGTTCTTGGCGAGGTGGTGAAGATGCGGCCTTGCGTAAAGATCGAATTTTTAATGACCGATCTTTGGGGATTGCGCT
TGATCGCTTAACTAAAACCTCTACGCTTGCAATAGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806D022

Antitoxin

Source ID Structure
AlphaFold DB A0A806D8U1

References