Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 774401..775025 Replicon chromosome
Accession NC_022886
Organism Helicobacter pylori BM012A

Toxin (Protein)


Gene name relE Uniprot ID V5NM94
Locus tag U063_RS03930 Protein ID WP_023592055.1
Coordinates 774759..775025 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V5NMW4
Locus tag U063_RS03925 Protein ID WP_023592054.1
Coordinates 774401..774778 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
U063_RS03895 769535..769771 + 237 WP_000335461.1 HypC/HybG/HupF family hydrogenase formation chaperone -
U063_RS03900 769789..770901 + 1113 WP_023592052.1 hydrogenase formation protein HypD -
U063_RS08420 770868..771139 + 272 Protein_728 hypothetical protein -
U063_RS03920 771960..774191 + 2232 WP_023591952.1 Hop family adhesin BabA -
U063_RS03925 774401..774778 + 378 WP_023592054.1 hypothetical protein Antitoxin
U063_RS03930 774759..775025 + 267 WP_023592055.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
U063_RS03935 775131..775655 - 525 WP_001135637.1 acyl-CoA thioesterase -
U063_RS03940 775795..776649 + 855 WP_023592056.1 SDR family oxidoreductase -
U063_RS03945 776642..777622 + 981 WP_000921458.1 iron ABC transporter permease -
U063_RS03950 777622..778389 + 768 WP_023592057.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10332.17 Da        Isoelectric Point: 8.0602

>T30336 WP_023592055.1 NC_022886:774759-775025 [Helicobacter pylori BM012A]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVENDELILLR
LGSHSELF

Download         Length: 267 bp

>T30336 NC_022886:774759-775025 [Helicobacter pylori BM012A]
GTGTTAAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGAAAGAACCGCTAGATCCCCAATTTAAAGATCATGCTTTGAAAGGAAAGTGGA
AACCTTTTAGGGAATGCCATATTAAAGCTGATATTTTGCTTGTGTATTTAGTGGAAAATGATGAGCTGATTTTGTTAAGG
TTAGGCAGTCATAGCGAGTTGTTTTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14715.70 Da        Isoelectric Point: 8.9992

>AT30336 WP_023592054.1 NC_022886:774401-774778 [Helicobacter pylori BM012A]
MPNSSTKKDYTKYSEKQLVNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
GHETPNIQTQQAMRDALNKETDLIVEDFSSYSDERKKALGVKTQP

Download         Length: 378 bp

>AT30336 NC_022886:774401-774778 [Helicobacter pylori BM012A]
ATGCCTAATTCTTCCACCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTGTTAACTTAATCCATCAATTAGAGCG
AAAAATTAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTT
GGGCATGAAACCCCAAACATTCAAACGCAACAAGCCATGAGAGACGCGCTCAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTACAGCGATGAAAGAAAAAAGGCGTTAGGTGTTAAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V5NM94

Antitoxin

Source ID Structure
AlphaFold DB V5NMW4

References