Detailed information of TA system TA030317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 4072093..4072598
• Replicon: chromosome
• Accession: NC_022806
• Organism: Pseudomonas aeruginosa PA1R

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: PA1R_RS18700
• Protein ID: WP_023518248.1
• Coordinates: 4072093..4072374 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: PA1R_RS18705
• Protein ID: WP_003083775.1
• Coordinates: 4072371..4072598 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PA1R_RS18675	4067344..4068693	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
PA1R_RS18680	4068742..4069428	+	687	WP_003083762.1	FadR family transcriptional regulator	-
PA1R_RS18685	4069529..4070263	+	735	WP_003117208.1	GntR family transcriptional regulator	-
PA1R_RS18690	4070467..4070853	+	387	WP_014602345.1	aegerolysin family protein	-
PA1R_RS18695	4070885..4071793	-	909	WP_003083769.1	LysR family transcriptional regulator	-
PA1R_RS18700	4072093..4072374	-	282	WP_023518248.1	type II toxin-antitoxin system toxin ParE	Toxin
PA1R_RS18705	4072371..4072598	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
PA1R_RS18710	4072774..4073394	-	621	WP_003101226.1	hypothetical protein	-
PA1R_RS18715	4073495..4073995	+	501	WP_003101228.1	LEA type 2 family protein	-
PA1R_RS18720	4074068..4074409	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
PA1R_RS18725	4074491..4075918	-	1428	WP_003083784.1	GABA permease	-
PA1R_RS18730	4076087..4077580	-	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10472.23 Da
• Isoelectric Point: 10.0435

>T30317 WP_023518248.1 NC_022806:c4072374-4072093 [Pseudomonas aeruginosa PA1R]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRIEITP

Nucleotide

• Length: 282 bp

>T30317 NC_022806:c4072374-4072093 [Pseudomonas aeruginosa PA1R]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATTGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGCCCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGATCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT30317 WP_003083775.1 NC_022806:c4072598-4072371 [Pseudomonas aeruginosa PA1R]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT30317 NC_022806:c4072598-4072371 [Pseudomonas aeruginosa PA1R]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9