Detailed information of TA system TA030308

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 5313903..5314431
• Replicon: chromosome
• Accession: NC_022738
• Organism: Pseudomonas sp. VLB120

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PVLB_RS24345
• Protein ID: WP_023382869.1
• Coordinates: 5313903..5314202 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2L1HF13
• Locus tag: PVLB_RS24350
• Protein ID: WP_023382870.1
• Coordinates: 5314192..5314431 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PVLB_RS24325	5310342..5311034	-	693	WP_041925565.1	toll/interleukin-1 receptor domain-containing protein	-
PVLB_RS29355	5311111..5311257	-	147	WP_023382865.1	hypothetical protein	-
PVLB_RS24330	5311655..5312566	+	912	WP_023382866.1	WYL domain-containing protein	-
PVLB_RS28470	5312926..5313781	-	856	Protein_4803	IS5 family transposase	-
PVLB_RS24345	5313903..5314202	-	300	WP_023382869.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PVLB_RS24350	5314192..5314431	-	240	WP_023382870.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
PVLB_RS24355	5314770..5317049	-	2280	WP_148299949.1	TonB-dependent siderophore receptor	-
PVLB_RS24360	5317206..5317925	+	720	WP_023382872.1	response regulator transcription factor	-
PVLB_RS24365	5317918..5319294	+	1377	WP_023382873.1	HAMP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-81)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11496.39 Da
• Isoelectric Point: 10.2270

>T30308 WP_023382869.1 NC_022738:c5314202-5313903 [Pseudomonas sp. VLB120]
MTYSLEFDARALKEWQKLGDTVRQQLKKKLASVLLNPRVEANRLHSLPDCYKIKLRSSGYRLVYQVIEQEVVVFVVAVDK
REREQAYLKAAERVVGKTS

Nucleotide

• Length: 300 bp

>T30308 NC_022738:c5314202-5313903 [Pseudomonas sp. VLB120]
ATGACCTATAGCCTTGAGTTCGATGCGCGAGCGCTAAAGGAATGGCAAAAGCTGGGGGATACGGTCCGGCAGCAACTCAA
GAAAAAACTCGCCTCGGTTTTGCTCAATCCGAGGGTTGAGGCGAACAGGCTGCATAGCTTGCCGGACTGCTACAAGATCA
AGCTGCGCAGTAGCGGCTACCGATTGGTCTACCAGGTGATCGAACAAGAGGTTGTAGTTTTTGTGGTAGCTGTGGATAAG
CGCGAGCGGGAACAGGCTTATCTTAAGGCGGCAGAGCGAGTGGTAGGTAAAACGTCATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9122.53 Da
• Isoelectric Point: 4.6182

>AT30308 WP_023382870.1 NC_022738:c5314431-5314192 [Pseudomonas sp. VLB120]
MASINVRIDDDLKIRAYRELERLGVTPSELMRQALQYVAERGQLPFKPVLMTDEDEALLAIVRERLADPQRVRVSLDDL

Nucleotide

• Length: 240 bp

>AT30308 NC_022738:c5314431-5314192 [Pseudomonas sp. VLB120]
ATGGCATCCATCAATGTTCGTATCGACGACGATCTCAAAATCCGAGCCTATCGTGAGCTTGAGCGGTTGGGTGTTACGCC
CTCCGAGCTCATGCGCCAAGCCTTGCAGTACGTCGCCGAGCGCGGGCAGTTGCCTTTTAAGCCTGTGCTCATGACTGATG
AAGATGAGGCGCTGCTAGCGATCGTTCGCGAGCGCCTTGCCGACCCTCAGCGAGTGAGGGTTTCGCTGGATGACCTATAG

Structures

Antitoxin

• AlphaFold DB: A0A2L1HF13