Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4034116..4035782 Replicon chromosome
Accession NC_022738
Organism Pseudomonas sp. VLB120

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PVLB_RS18320 Protein ID WP_041925530.1
Coordinates 4034116..4034964 (+) Length 283 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag PVLB_RS18325 Protein ID WP_027907431.1
Coordinates 4034970..4035782 (+) Length 271 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVLB_RS18295 4030110..4030955 + 846 WP_023381728.1 ABC transporter ATP-binding protein -
PVLB_RS18300 4030987..4031988 + 1002 WP_023381729.1 ABC transporter substrate-binding protein -
PVLB_RS18305 4032017..4032793 + 777 WP_023381730.1 ABC transporter permease -
PVLB_RS18310 4032793..4033557 + 765 WP_023381731.1 SDR family oxidoreductase -
PVLB_RS18315 4033572..4034111 + 540 WP_023381732.1 cupin domain-containing protein -
PVLB_RS18320 4034116..4034964 + 849 WP_041925530.1 alpha/beta hydrolase Toxin
PVLB_RS18325 4034970..4035782 + 813 WP_027907431.1 IclR family transcriptional regulator Antitoxin
PVLB_RS18330 4035784..4036581 + 798 WP_023381735.1 SDR family oxidoreductase -
PVLB_RS18335 4036574..4038256 + 1683 WP_023381736.1 thiamine pyrophosphate-binding protein -
PVLB_RS18340 4038267..4039070 + 804 WP_023381737.1 aspartate dehydrogenase -
PVLB_RS18345 4039081..4040571 + 1491 WP_023381738.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(38-265)

Antitoxin

Transcription regulator IclR, N-terminal

(16-65)


Sequences

Toxin        


Download         Length: 283 a.a.        Molecular weight: 29568.01 Da        Isoelectric Point: 6.8859

>T30307 WP_041925530.1 NC_022738:4034116-4034964 [Pseudomonas sp. VLB120]
MIPLMPTPSLLDQRFAERLLRLDGGQLAVRQAGDGDAVVLLHGIGSGAASWLHVAMGLSERARVLAWDAPGYGQSSPLPM
AAPSARDYAGRLLQALDTLGIERCVLVGHSLGALTASAFAQACPERVNRLVLISPARGYGAVPDQGRAVRAERLHNLGQL
GIERMARERSARLLSANASAEAQAWVHWNMARLKPHGYRQAIELLCGDDLLRYAPLAVACQVHCGSADGITLPEDCAALA
AALAAPFDLIAGAGHACAIEQPDTVTGLLARALDASLTGSVL

Download         Length: 849 bp

>T30307 NC_022738:4034116-4034964 [Pseudomonas sp. VLB120]
ATGATACCGCTCATGCCCACCCCCTCCCTGCTCGATCAGCGCTTCGCCGAACGTCTGCTGCGCCTGGATGGCGGCCAGTT
GGCCGTGCGCCAAGCCGGCGACGGTGACGCCGTGGTGCTGCTGCACGGCATCGGCTCGGGCGCGGCCAGCTGGCTGCACG
TGGCCATGGGTTTGAGCGAGCGGGCTCGGGTACTGGCCTGGGACGCACCGGGCTATGGCCAGTCCTCGCCTTTGCCGATG
GCTGCGCCCAGCGCACGGGACTATGCCGGACGCCTGCTGCAGGCACTGGATACCTTGGGTATCGAGCGTTGCGTGCTGGT
CGGCCACTCCCTCGGGGCACTGACCGCCAGCGCCTTCGCCCAGGCCTGCCCTGAGCGCGTCAACCGCCTGGTACTGATCA
GCCCGGCGCGCGGATACGGCGCTGTGCCGGATCAAGGCCGGGCGGTGCGCGCCGAGCGCCTGCACAACCTTGGGCAACTG
GGCATCGAACGCATGGCCCGCGAGCGCAGCGCACGGTTGCTGTCGGCAAACGCCAGCGCCGAGGCGCAGGCCTGGGTGCA
CTGGAACATGGCGCGGCTCAAGCCCCATGGCTACCGCCAAGCCATCGAATTGCTGTGCGGCGACGACCTGCTGCGCTACG
CGCCCCTGGCGGTTGCGTGCCAGGTGCACTGCGGCAGCGCAGACGGCATCACCCTGCCCGAGGACTGCGCGGCACTCGCC
GCTGCACTGGCCGCGCCCTTCGACCTGATTGCCGGCGCCGGCCATGCCTGCGCCATCGAACAACCTGACACGGTGACGGG
CCTGCTGGCCCGCGCCCTCGACGCCTCTCTGACAGGTAGCGTGCTATGA

Antitoxin


Download         Length: 271 a.a.        Molecular weight: 29767.26 Da        Isoelectric Point: 6.6423

>AT30307 WP_027907431.1 NC_022738:4034970-4035782 [Pseudomonas sp. VLB120]
MDPLKENQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLSLPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLRLGF
EYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVTVGTRLPAHATVLGRILLADLSLAELR
ELYPEEHLEQYSPCTPKTVLELFDLVQADRLRGYVSGEGFFESTISTVAAPVRDASGQVVAALGLTIPTVQIGHVNFDNL
LGQVRGSADELSRLLNYRPGSGHVTALMRD

Download         Length: 813 bp

>AT30307 NC_022738:4034970-4035782 [Pseudomonas sp. VLB120]
ATGGATCCGTTGAAGGAAAACCAGGACAAGTACATCGTCCCGGGCCTGGAGCGCGGCCTGCTGTTGCTGTGCGAATTCAG
CCGGCAGAACCGCACCCTGACCGCCCCCGAACTGGCCCGGCGTCTGTCGCTGCCACGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAAACCATGGGGTTCGTCACCCGCAGCGGCAACGAATACCGCCTCGGCATGTCGGTGCTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAGCTTGGCCAGCCGTTGCTGGCGCGGCTGTGCGATCACCTCAACTACCCCAG
CAATCTGGTGGTACGCGATGGCCGCTCGATTGTCTACGTGGCCAAGGTCTCGCCGCCTTCGGTGTTCTCCAGCGCGGTCA
CCGTGGGTACCCGCCTGCCAGCCCATGCCACCGTGCTCGGACGTATCCTGCTGGCCGACCTGAGCCTGGCCGAACTGCGT
GAGCTGTACCCCGAAGAGCATCTGGAGCAGTACTCGCCGTGCACGCCCAAAACCGTGCTGGAGCTGTTCGACCTGGTGCA
GGCCGACCGCCTGCGTGGCTATGTCAGCGGCGAGGGCTTCTTCGAGTCGACCATCTCCACGGTGGCGGCGCCGGTGCGCG
ATGCCAGCGGCCAGGTAGTCGCAGCCCTCGGCCTGACCATCCCCACGGTGCAGATCGGCCACGTCAACTTCGACAACCTG
CTCGGCCAGGTGCGTGGCAGCGCCGACGAACTGTCGCGCCTGCTCAACTACCGACCCGGCAGTGGCCATGTCACCGCGTT
GATGAGGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References