Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2043894..2044684 Replicon chromosome
Accession NC_022737
Organism Staphylococcus pasteuri SP1

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag STP1_RS09910 Protein ID WP_023374901.1
Coordinates 2043894..2044358 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag STP1_RS09915 Protein ID WP_023374902.1
Coordinates 2044370..2044684 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STP1_RS09890 2039487..2039948 + 462 WP_002450845.1 SUF system NifU family Fe-S cluster assembly protein -
STP1_RS09895 2040122..2041519 + 1398 WP_002450844.1 Fe-S cluster assembly protein SufB -
STP1_RS09900 2041587..2042636 - 1050 WP_023374899.1 site-specific integrase -
STP1_RS12845 2042750..2042926 + 177 WP_159033335.1 hypothetical protein -
STP1_RS09905 2042909..2043880 - 972 WP_023374900.1 hypothetical protein -
STP1_RS09910 2043894..2044358 - 465 WP_023374901.1 ImmA/IrrE family metallo-endopeptidase Toxin
STP1_RS09915 2044370..2044684 - 315 WP_023374902.1 helix-turn-helix domain-containing protein Antitoxin
STP1_RS09920 2044836..2045072 + 237 WP_002500133.1 helix-turn-helix domain-containing protein -
STP1_RS12965 2045086..2045262 + 177 WP_023374903.1 hypothetical protein -
STP1_RS09925 2045254..2045631 - 378 WP_023374904.1 DUF2513 domain-containing protein -
STP1_RS09930 2045679..2046434 + 756 WP_023374905.1 phage regulatory protein/antirepressor Ant -
STP1_RS12970 2046572..2046748 - 177 WP_167321433.1 hypothetical protein -
STP1_RS09935 2046808..2047023 + 216 WP_023374907.1 MarR family transcriptional regulator -
STP1_RS09940 2047020..2047199 + 180 WP_023374908.1 DUF1270 family protein -
STP1_RS09945 2047271..2047498 + 228 WP_023374909.1 hypothetical protein -
STP1_RS09950 2047491..2047976 + 486 WP_023374910.1 siphovirus Gp157 family protein -
STP1_RS09955 2047977..2048762 + 786 WP_023374911.1 AAA family ATPase -
STP1_RS09960 2048792..2049346 + 555 WP_023374912.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2040122..2082495 42373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(18-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18263.84 Da        Isoelectric Point: 6.1600

>T30306 WP_023374901.1 NC_022737:c2044358-2043894 [Staphylococcus pasteuri SP1]
MGLYEEMLIEHDYIEVKETDVMPSDLHGLWLNDLILINSNLSETRKAEVLYEELAHHKLTYGNILDQSKWINRKFENYAK
RHGYEAALPLRIIVEAHHYGVSNLYELAQYVQLSEEHVLEILKHYKNKYGIGTHLGEYLITFDPLRVYKYQNIK

Download         Length: 465 bp

>T30306 NC_022737:c2044358-2043894 [Staphylococcus pasteuri SP1]
ATGGGTTTATATGAAGAGATGTTGATAGAACATGATTACATAGAAGTAAAAGAAACTGATGTTATGCCTAGTGACTTACA
CGGTTTGTGGTTAAATGACTTAATTTTAATCAATAGCAACCTATCAGAAACACGAAAGGCCGAAGTCTTATACGAAGAAT
TAGCGCATCATAAACTTACATATGGGAATATCTTAGACCAGTCTAAATGGATTAACCGTAAGTTTGAAAACTACGCTAAA
CGTCATGGATACGAGGCTGCATTGCCTTTAAGAATTATCGTAGAAGCACATCACTACGGTGTAAGTAACTTATACGAACT
AGCGCAGTATGTTCAATTAAGTGAAGAACACGTATTAGAAATATTGAAACATTACAAAAATAAATATGGTATTGGAACTC
ACTTGGGAGAATACTTAATTACATTTGATCCGTTGAGAGTGTATAAGTATCAAAATATAAAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12031.56 Da        Isoelectric Point: 7.1667

>AT30306 WP_023374902.1 NC_022737:c2044684-2044370 [Staphylococcus pasteuri SP1]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAFLMGWIDESDEQPQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT30306 NC_022737:c2044684-2044370 [Staphylococcus pasteuri SP1]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTAGCTGAACTAGGAAGAAAAATCGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGTGGAAATATCAAAAATCTTAAAAACGATACTATCGAAAGCATAGCTACGG
CATTAAATGTTAACCCTGCATTTTTGATGGGTTGGATAGATGAAAGTGATGAACAACCACAACATCGTGCAGCTCATCTT
GAAGGCGAATTAACAGATGATGAATGGCAACGTGTATTAGACTACGCAGATTATATTAGAAGTAAACGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References