Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 592021..592531 Replicon chromosome
Accession NC_022737
Organism Staphylococcus pasteuri SP1

Toxin (Protein)


Gene name TsdT Uniprot ID A0A2V3Z9H5
Locus tag STP1_RS02755 Protein ID WP_023373301.1
Coordinates 592021..592227 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A364UNN3
Locus tag STP1_RS02760 Protein ID WP_002466760.1
Coordinates 592238..592531 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STP1_RS02740 587611..588972 - 1362 WP_023373295.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
STP1_RS02745 588988..590058 - 1071 WP_023373297.1 D-alanine--D-alanine ligase -
STP1_RS02750 590415..591605 + 1191 WP_023373299.1 rod shape-determining protein RodA -
STP1_RS12765 591745..591882 - 138 WP_002466770.1 hypothetical protein -
STP1_RS02755 592021..592227 - 207 WP_023373301.1 heavy-metal-associated domain-containing protein Toxin
STP1_RS02760 592238..592531 - 294 WP_002466760.1 copper-sensing transcriptional repressor CsoR Antitoxin
STP1_RS02765 592720..594204 + 1485 WP_023373303.1 cardiolipin synthase -
STP1_RS02770 594326..594970 + 645 WP_023373305.1 HD domain-containing protein -
STP1_RS02775 595010..595879 - 870 WP_002466746.1 membrane protein insertase YidC -
STP1_RS02780 595968..596609 - 642 WP_023373306.1 thiamine phosphate synthase -
STP1_RS02785 596610..597401 - 792 WP_023373308.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7628.58 Da        Isoelectric Point: 4.0101

>T30304 WP_023373301.1 NC_022737:c592227-592021 [Staphylococcus pasteuri SP1]
VQQKIVYTAGIETQEQSDAIKNLLTEMIGVHQVEIDINTGNISIEFETPANLNSIEKEIYDAGFKVLY

Download         Length: 207 bp

>T30304 NC_022737:c592227-592021 [Staphylococcus pasteuri SP1]
GTGCAACAAAAAATTGTATATACAGCTGGAATAGAAACACAGGAACAATCTGATGCTATAAAAAATCTTTTAACTGAAAT
GATAGGTGTACATCAAGTTGAAATCGATATCAATACTGGAAATATTTCAATTGAATTTGAAACACCTGCAAATTTAAATA
GTATTGAAAAAGAAATTTATGATGCTGGATTCAAAGTGCTCTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11199.74 Da        Isoelectric Point: 6.3263

>AT30304 WP_002466760.1 NC_022737:c592531-592238 [Staphylococcus pasteuri SP1]
VTEQDHAHHSEQIKVNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIADKVNQGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT30304 NC_022737:c592531-592238 [Staphylococcus pasteuri SP1]
GTGACAGAACAAGATCATGCACATCACTCTGAACAAATTAAAGTAAATTTAAAATCGAGATTAAACCGTATTGAAGGTCA
AGTTAGAGCTATTAATCGAATGATAGAAGAGGATGTTTATTGCGATGATGTGCTAACTCAAATTAGAGCTACACGTTCTG
CATTAAATAGTGTAGCCACTAAATTATTAGAACAACATATGAAAAGTTGTATTGCAGATAAAGTAAATCAGGGCCATCAA
GAAGAAGCAATGGAAGAACTACTCGTTACATTTCAAAAACTAATGAAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3Z9H5

Antitoxin

Source ID Structure
AlphaFold DB A0A364UNN3

References