Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 580880..581409 Replicon chromosome
Accession NC_022737
Organism Staphylococcus pasteuri SP1

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PXE7
Locus tag STP1_RS02700 Protein ID WP_002451625.1
Coordinates 580880..581242 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag STP1_RS02705 Protein ID WP_002451626.1
Coordinates 581239..581409 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STP1_RS02680 577907..578677 - 771 WP_002451621.1 RNA polymerase sigma factor SigB -
STP1_RS02685 578652..579131 - 480 WP_002466768.1 anti-sigma B factor RsbW -
STP1_RS02690 579133..579459 - 327 WP_002466754.1 anti-sigma factor antagonist -
STP1_RS02695 579554..580555 - 1002 WP_023373284.1 PP2C family protein-serine/threonine phosphatase -
STP1_RS02700 580880..581242 - 363 WP_002451625.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
STP1_RS02705 581239..581409 - 171 WP_002451626.1 hypothetical protein Antitoxin
STP1_RS02710 581501..582649 - 1149 WP_023373286.1 alanine racemase -
STP1_RS02715 582701..583075 - 375 WP_023373287.1 holo-ACP synthase -
STP1_RS02720 583108..583605 - 498 WP_041613624.1 PH domain-containing protein -
STP1_RS02725 583592..585118 - 1527 WP_023373291.1 PH domain-containing protein -
STP1_RS02730 585111..585584 - 474 WP_023373293.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13562.68 Da        Isoelectric Point: 9.9783

>T30303 WP_002451625.1 NC_022737:c581242-580880 [Staphylococcus pasteuri SP1]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFNHSKT

Download         Length: 363 bp

>T30303 NC_022737:c581242-580880 [Staphylococcus pasteuri SP1]
ATGATTAGAAGAGGAGATGTTTATCTAGCAGATTTATCGCCTGTTCAAGGGTCAGAACAAGGGGGAGTAAGACCCGTCGT
CATTATCCAAAATGACACAGGCAATAAATATAGTCCTACTGTTATTGTTGCTGCAATTACTGGAAGGATTAATAAAGCTA
AGATACCTACACATGTTGAAATTGAAAAGAAAAAGTACAAACTTGATAAGGACTCAGTTATTTTACTAGAACAAATTCGT
ACTTTAGATAAAAATCGTTTAAAAGAAAAACTCACATATTTGTCTGATAACAAAATGAAAGAAGTAGATTACGCCCTAGA
CATCAGTCTAGGTTTACATAATTTCAATCATTCTAAGACATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT30303 WP_002451626.1 NC_022737:c581409-581239 [Staphylococcus pasteuri SP1]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp

>AT30303 NC_022737:c581409-581239 [Staphylococcus pasteuri SP1]
ATGTTATCTTTTAATCAAAATAGAAGTTACAGTTTAGAGCAATCTTTAAAAGAAGGTTATGCACAAATGGCTGATTTAAA
TCTCTCCCTAGCAACCGAAGCTTTTCCTATTGAGTGTGAAGCGTGCGATTGCAATGAAACATATTTAACTTCTAACGCTA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PXE7

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References