Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 429842..430648 Replicon chromosome
Accession NC_022737
Organism Staphylococcus pasteuri SP1

Toxin (Protein)


Gene name tsbT Uniprot ID A0A2V3ZCG8
Locus tag STP1_RS01910 Protein ID WP_023373065.1
Coordinates 429842..430021 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A2V3ZD14
Locus tag STP1_RS01915 Protein ID WP_023373067.1
Coordinates 430049..430648 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STP1_RS01885 424944..425567 - 624 WP_023373056.1 response regulator transcription factor -
STP1_RS01890 425588..426700 - 1113 WP_023373058.1 GAF domain-containing sensor histidine kinase -
STP1_RS01895 426878..427708 + 831 WP_023373060.1 RluA family pseudouridine synthase -
STP1_RS01900 427767..429152 - 1386 WP_023373062.1 class II fumarate hydratase -
STP1_RS01905 429306..429698 - 393 WP_023373063.1 hypothetical protein -
STP1_RS01910 429842..430021 - 180 WP_023373065.1 hypothetical protein Toxin
STP1_RS01915 430049..430648 - 600 WP_023373067.1 glucosamine-6-phosphate isomerase Antitoxin
STP1_RS01920 430828..431298 - 471 WP_023373069.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
STP1_RS01925 431295..432428 - 1134 WP_023373071.1 tRNA epoxyqueuosine(34) reductase QueG -
STP1_RS01930 432684..433406 - 723 WP_023373073.1 amino acid ABC transporter ATP-binding protein -
STP1_RS01935 433399..434859 - 1461 WP_023373075.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6875.19 Da        Isoelectric Point: 3.9291

>T30302 WP_023373065.1 NC_022737:c430021-429842 [Staphylococcus pasteuri SP1]
MTQNKDSKTNHHEEENAMVTDLDDLKDLGKEMEQISEENDEEKLNQSHDSDVRSDLDQD

Download         Length: 180 bp

>T30302 NC_022737:c430021-429842 [Staphylococcus pasteuri SP1]
ATGACTCAAAATAAAGATTCTAAAACAAATCACCATGAAGAAGAAAATGCAATGGTAACCGATTTAGATGATTTAAAAGA
CTTAGGAAAAGAAATGGAACAAATTTCTGAAGAAAATGATGAAGAAAAATTAAATCAATCTCATGATTCAGATGTTCGTT
CTGATTTAGATCAAGATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22624.58 Da        Isoelectric Point: 5.3571

>AT30302 WP_023373067.1 NC_022737:c430648-430049 [Staphylococcus pasteuri SP1]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDKNQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDENGHLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT30302 NC_022737:c430648-430049 [Staphylococcus pasteuri SP1]
ATGGCAATGAACTTTAAAGTATTTGAAGATAAACAAAGAGTAGCTGAATATACAGCAGACATTTTGAGAAAACAATTTAA
TAACAACCCAATGACTATCGCAGGTGTTCATTTAACAAAAGATCATGCACCTGTATTAGATGAATTAAAAAAGAATGTTG
ATTTACATGCAGTTGATTTCAGTCAAATTAATATTTTAGATTATGATAAAAATCAATCATATTATGAAGCGTTAGGTGTA
CCACAAAGCCAAATTTATTCATTATCATATAACCAAGATGCTAATGACTTTATTTCAGATAAAATTAAAACGAAAGAAAA
TAAAGGTAAATTAGTATTACAAGTAGTTTCAATTGATGAAAATGGTCATTTAGATGTAAGTGTAAGACAAGGTTTACTAG
AAGCACGCGAAATCTTCTTAGTTGTTACTGGTAGTAATAAACGTGAAGTAGTCGAAAAATTATATAACGAAAATGGAAAA
TCTAACTTTGAACCTGCAGACTTAAAAGCGCACCGTATGGTTAACGTTATTTTAGATAAAGAAGCAGCAGCTGGATTACC
TGAAGACGTGAAAGAATACTTCACAGCTCGCTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3ZCG8

Antitoxin

Source ID Structure
AlphaFold DB A0A2V3ZD14

References