Detailed information of TA system TA030298

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 2072763..2073369
• Replicon: chromosome
• Accession: NC_022665
• Organism: Streptococcus suis T15

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A0Z8ZB64
• Locus tag: T15_RS10370
• Protein ID: WP_012775364.1
• Coordinates: 2072763..2073092 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A822VQD8
• Locus tag: T15_RS10375
• Protein ID: WP_023371687.1
• Coordinates: 2073082..2073369 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
T15_RS10340	2068179..2069909	-	1731	WP_023371683.1	membrane protein	-
T15_RS10345	2070272..2071144	-	873	WP_014736465.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
T15_RS10350	2071163..2071642	-	480	WP_074389919.1	DUF1697 domain-containing protein	-
T15_RS10355	2071706..2071963	-	258	WP_013730620.1	Txe/YoeB family addiction module toxin	-
T15_RS10360	2071965..2072225	-	261	WP_002939010.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
T15_RS10365	2072301..2072756	-	456	WP_012028534.1	8-oxo-dGTP diphosphatase	-
T15_RS10370	2072763..2073092	-	330	WP_012775364.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
T15_RS10375	2073082..2073369	-	288	WP_023371687.1	hypothetical protein	Antitoxin
T15_RS10380	2073467..2073835	-	369	WP_023371689.1	hypothetical protein	-
T15_RS10385	2073828..2074397	-	570	WP_012775700.1	ribonuclease M5	-
T15_RS10390	2074381..2075163	-	783	WP_012028536.1	TatD family hydrolase	-
T15_RS10395	2075270..2075407	-	138	WP_002939016.1	50S ribosomal protein L34	-
T15_RS10400	2075650..2076737	+	1088	Protein_2000	IS30 family transposase	-
T15_RS10405	2077049..2078044	-	996	WP_023371691.1	protein jag	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2058500..2075163	16663
	-	flank	IS/Tn	-	-	2076195..2076737	542

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-95)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12562.52 Da
• Isoelectric Point: 7.1991

>T30298 WP_012775364.1 NC_022665:c2073092-2072763 [Streptococcus suis T15]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Nucleotide

• Length: 330 bp

>T30298 NC_022665:c2073092-2072763 [Streptococcus suis T15]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10892.48 Da
• Isoelectric Point: 4.4616

>AT30298 WP_023371687.1 NC_022665:c2073369-2073082 [Streptococcus suis T15]
MITINKDAKVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Nucleotide

• Length: 288 bp

>AT30298 NC_022665:c2073369-2073082 [Streptococcus suis T15]
TTGATAACTATAAATAAAGATGCCAAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Structures

Toxin

• AlphaFold DB: A0A0Z8ZB64

Antitoxin

• AlphaFold DB: A0A822VQD8