Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1605167..1605841 Replicon chromosome
Accession NC_022665
Organism Streptococcus suis T15

Toxin (Protein)


Gene name hicA Uniprot ID A0A123U128
Locus tag T15_RS08045 Protein ID WP_009910449.1
Coordinates 1605167..1605349 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A123TH46
Locus tag T15_RS08050 Protein ID WP_023371005.1
Coordinates 1605389..1605841 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
T15_RS08015 1600459..1600731 + 273 WP_041179486.1 DNA-binding protein -
T15_RS08020 1600728..1601591 + 864 WP_023370995.1 primase alpha helix C-terminal domain-containing protein -
T15_RS08025 1601588..1603111 + 1524 WP_023370997.1 DNA primase family protein -
T15_RS08030 1603446..1603886 + 441 WP_023370999.1 hypothetical protein -
T15_RS08035 1603956..1604456 + 501 WP_023371001.1 hypothetical protein -
T15_RS08040 1604597..1604983 + 387 WP_023371003.1 hypothetical protein -
T15_RS08045 1605167..1605349 + 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin Toxin
T15_RS08050 1605389..1605841 + 453 WP_023371005.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
T15_RS08055 1605953..1606162 + 210 WP_023371007.1 hypothetical protein -
T15_RS08060 1606814..1607637 - 824 Protein_1535 hypothetical protein -
T15_RS08065 1607639..1608433 - 795 WP_023371013.1 hypothetical protein -
T15_RS08070 1608435..1608752 - 318 WP_023371015.1 PadR family transcriptional regulator -
T15_RS08075 1608749..1608913 - 165 WP_023371017.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1595215..1608913 13698


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6681.93 Da        Isoelectric Point: 10.8207

>T30296 WP_009910449.1 NC_022665:1605167-1605349 [Streptococcus suis T15]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKVGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T30296 NC_022665:1605167-1605349 [Streptococcus suis T15]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACTAAAGGTGGTAAGGGGTCTCA
CGTTAAACTTGAAAAAGTAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16685.68 Da        Isoelectric Point: 4.0098

>AT30296 WP_023371005.1 NC_022665:1605389-1605841 [Streptococcus suis T15]
MLVTYPALFYYDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINALSLADNNPF
RDDKDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp

>AT30296 NC_022665:1605389-1605841 [Streptococcus suis T15]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTAACGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAGGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGTGATATTCCCACTCCTACCCCTATTAACGCTTTATCATTGGCTGATAATAACCCTTTC
CGTGATGATAAGGACATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A123U128

Antitoxin

Source ID Structure
AlphaFold DB A0A123TH46

References