Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1110006..1110498 Replicon chromosome
Accession NC_022665
Organism Streptococcus suis T15

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag T15_RS05550 Protein ID WP_011922404.1
Coordinates 1110241..1110498 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag T15_RS05545 Protein ID WP_012775104.1
Coordinates 1110006..1110257 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
T15_RS05525 1105573..1106319 + 747 WP_011922411.1 ABC transporter permease -
T15_RS05530 1106321..1107055 + 735 WP_011922410.1 ABC transporter permease -
T15_RS05535 1107191..1107943 + 753 WP_011922409.1 ABC transporter ATP-binding protein -
T15_RS05540 1107944..1109914 + 1971 WP_023370348.1 FtsX-like permease family protein -
T15_RS05545 1110006..1110257 + 252 WP_012775104.1 hypothetical protein Antitoxin
T15_RS05550 1110241..1110498 + 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
T15_RS05555 1110537..1111202 + 666 WP_012775103.1 response regulator transcription factor -
T15_RS05560 1111199..1112140 + 942 WP_023370350.1 sensor histidine kinase -
T15_RS05565 1112216..1113724 + 1509 WP_023370352.1 phosphomannomutase/phosphoglucomutase -
T15_RS05570 1113787..1114857 - 1071 WP_023370354.1 tyrosine recombinase XerS -
T15_RS11430 1115146..1115445 - 300 WP_079268869.1 zinc-ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T30294 WP_011922404.1 NC_022665:1110241-1110498 [Streptococcus suis T15]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T30294 NC_022665:1110241-1110498 [Streptococcus suis T15]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT30294 WP_012775104.1 NC_022665:1110006-1110257 [Streptococcus suis T15]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT30294 NC_022665:1110006-1110257 [Streptococcus suis T15]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References