Detailed information of TA system TA030290

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 4212462..4213087
• Replicon: chromosome
• Accession: NC_022663
• Organism: Mycobacterium kansasii ATCC 12478

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: X7YX14
• Locus tag: MKAN_RS18350
• Protein ID: WP_023370764.1
• Coordinates: 4212686..4213087 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: X7YXT3
• Locus tag: MKAN_RS18345
• Protein ID: WP_023370762.1
• Coordinates: 4212462..4212689 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKAN_RS18330	4207757..4208923	+	1167	WP_023370756.1	LarC family nickel insertion protein	-
MKAN_RS18335	4208930..4210111	-	1182	WP_160937733.1	MFS transporter	-
MKAN_RS18340	4210353..4212341	-	1989	WP_080674253.1	SEC-C domain-containing protein	-
MKAN_RS18345	4212462..4212689	+	228	WP_023370762.1	hypothetical protein	Antitoxin
MKAN_RS18350	4212686..4213087	+	402	WP_023370764.1	PIN domain-containing protein	Toxin
MKAN_RS18355	4213172..4214128	+	957	WP_023370766.1	class I SAM-dependent methyltransferase	-
MKAN_RS18360	4214212..4215432	+	1221	WP_023370767.1	NarK/NasA family nitrate transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14053.99 Da
• Isoelectric Point: 6.3696

>T30290 WP_023370764.1 NC_022663:4212686-4213087 [Mycobacterium kansasii ATCC 12478]
VIALLDSNVLIALVVAEHVHHDVAAAWLSARDNGFATCPITQGSLVRFLMRTGQPAAVAREVVGAVETAKRHEFWPDSVS
FADVEIGGVVGHRQVTDAYLAQLARSRNGQLATLDSGLAHLHSDVAVLIPTAG

Nucleotide

• Length: 402 bp

>T30290 NC_022663:4212686-4213087 [Mycobacterium kansasii ATCC 12478]
GTGATCGCGCTGCTGGACTCGAACGTGCTGATCGCACTGGTGGTCGCCGAACACGTCCATCACGACGTCGCCGCGGCATG
GCTGTCCGCGCGCGACAACGGCTTCGCGACGTGCCCAATCACGCAGGGAAGTCTGGTTCGATTCTTGATGCGGACGGGCC
AACCCGCCGCAGTTGCGCGGGAGGTGGTCGGAGCTGTCGAAACCGCAAAGCGCCACGAGTTCTGGCCCGACAGCGTCTCT
TTCGCCGATGTCGAGATCGGAGGGGTGGTCGGTCACCGACAGGTGACCGATGCCTACCTGGCGCAGCTGGCCCGAAGCCG
CAACGGGCAGTTGGCGACTCTCGATAGTGGACTGGCGCACTTGCACAGCGACGTCGCGGTCCTCATTCCCACGGCCGGCT
GA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8012.00 Da
• Isoelectric Point: 4.7377

>AT30290 WP_023370762.1 NC_022663:4212462-4212689 [Mycobacterium kansasii ATCC 12478]
VRTTIDLPDDLHKQALAIARDTRRTLSETVADLMRRGLGAGGAAAISTDPRTGLPLVNVGKVVTSEDVRSLEDEE

Nucleotide

• Length: 228 bp

>AT30290 NC_022663:4212462-4212689 [Mycobacterium kansasii ATCC 12478]
GTGCGTACCACCATTGATCTTCCCGACGACCTCCACAAGCAAGCGCTGGCCATCGCCCGGGACACGCGCCGGACGTTGAG
TGAAACCGTCGCCGATCTCATGCGACGGGGCCTGGGGGCCGGCGGCGCCGCCGCGATCTCCACTGACCCGAGAACCGGGC
TGCCTCTGGTGAACGTCGGCAAAGTTGTCACCTCCGAGGACGTGCGCTCGTTGGAGGATGAGGAGTGA

Structures

Toxin

• AlphaFold DB: X7YX14

Antitoxin

• AlphaFold DB: X7YXT3