Detailed information of TA system TA030287

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): CapRel-ATcapRel/-
• Location: 1986136..1987040
• Replicon: chromosome
• Accession: NC_022663
• Organism: Mycobacterium kansasii ATCC 12478

Toxin (Protein)

• Gene name: capRel
• Uniprot ID: X7ZGG2
• Locus tag: MKAN_RS08390
• Protein ID: WP_023367202.1
• Coordinates: 1986387..1987040 (-)
• Length: 218 a.a.

Antitoxin (Protein)

• Gene name: ATcapRel
• Uniprot ID: X7ZF14
• Locus tag: MKAN_RS08385
• Protein ID: WP_023367200.1
• Coordinates: 1986136..1986390 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKAN_RS08370	1982079..1983551	-	1473	WP_023367193.1	O-antigen ligase family protein	-
MKAN_RS08375	1983548..1984942	-	1395	WP_023367196.1	polysaccharide biosynthesis tyrosine autokinase	-
MKAN_RS08380	1985308..1986102	+	795	WP_036393567.1	FkbM family methyltransferase	-
MKAN_RS08385	1986136..1986390	-	255	WP_023367200.1	hypothetical protein	Antitoxin
MKAN_RS08390	1986387..1987040	-	654	WP_023367202.1	RelA/SpoT domain-containing protein	Toxin
MKAN_RS08410	1988297..1989442	-	1146	WP_036393847.1	hypothetical protein	-
MKAN_RS08415	1989630..1990283	-	654	WP_080674044.1	GNAT family N-acetyltransferase	-
MKAN_RS08420	1990305..1991594	-	1290	WP_023367211.1	molybdopterin molybdotransferase MoeA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (53-150)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 218 a.a.
• Molecular weight: 24338.76 Da
• Isoelectric Point: 8.9815

>T30287 WP_023367202.1 NC_022663:c1987040-1986387 [Mycobacterium kansasii ATCC 12478]
VSTTIGPNEHGIEEIFQALDTLEAWRAAHARPLQAATMGLRSRVATMGCSQIEVSQRLERIPTIIDKLRREPGMNLGRMA
DIGGCRAVLRDVDEVRRVQSRYAGAAVTVRTRDYVEQPKSDGYRAVHVIVRYHGRLIEVQLRTQVQHEWAYTVESVTSRF
GLDIKAGGGPRPVHDWFVAVSEAMALEEYGEPVAPELLRRVDTLRAAAQPYLQGVRR

Nucleotide

• Length: 654 bp

>T30287 NC_022663:c1987040-1986387 [Mycobacterium kansasii ATCC 12478]
GTGAGCACCACCATCGGACCCAACGAGCACGGCATCGAGGAAATTTTTCAAGCCCTCGACACGCTTGAAGCGTGGCGCGC
TGCGCATGCCCGTCCCCTTCAGGCCGCGACCATGGGCCTGCGTTCGCGGGTAGCCACGATGGGCTGCTCGCAGATCGAGG
TATCACAGCGGCTAGAACGCATTCCGACGATCATCGACAAACTGCGTCGCGAACCGGGCATGAACCTCGGGCGGATGGCA
GACATCGGTGGCTGTCGAGCCGTTTTGCGCGACGTCGACGAGGTGCGGCGCGTACAGTCCCGCTACGCCGGCGCCGCCGT
TACCGTCAGAACCAGGGATTACGTTGAGCAGCCAAAGTCGGACGGCTATCGCGCCGTACATGTGATCGTCCGCTACCACG
GTCGCCTGATCGAGGTTCAGCTGCGAACGCAGGTGCAACACGAATGGGCCTATACGGTGGAGAGCGTTACGTCGCGCTTC
GGGCTCGACATCAAGGCCGGTGGCGGGCCGCGGCCGGTGCATGACTGGTTCGTAGCGGTGTCAGAAGCGATGGCGCTGGA
AGAATACGGTGAGCCGGTAGCGCCGGAGCTGTTGCGGCGTGTAGATACACTGAGGGCAGCCGCCCAGCCTTACCTGCAAG
GAGTACGACGATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9265.50 Da
• Isoelectric Point: 5.5094

>AT30287 WP_023367200.1 NC_022663:c1986390-1986136 [Mycobacterium kansasii ATCC 12478]
MTASLNHFLLVFDHSRAELVDLKNFGTDAKSAMAEYARLEREHMGKSDAIEIVLIGSDSLETVKVTHANYFDGTVAVSKY
FAGI

Nucleotide

• Length: 255 bp

>AT30287 NC_022663:c1986390-1986136 [Mycobacterium kansasii ATCC 12478]
ATGACTGCATCGCTGAATCACTTCTTGCTCGTCTTCGACCACAGCCGGGCCGAGCTGGTGGACCTGAAGAACTTCGGCAC
CGACGCGAAGAGTGCGATGGCGGAATACGCCCGCTTAGAGCGAGAGCACATGGGCAAGTCGGACGCGATTGAGATCGTGC
TGATCGGTTCCGATTCACTGGAAACGGTAAAGGTCACGCACGCCAACTACTTCGATGGCACCGTTGCGGTCTCAAAGTAT
TTTGCTGGCATCTAA

Structures

Toxin

• AlphaFold DB: X7ZGG2

Antitoxin

• AlphaFold DB: X7ZF14