Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 105204..105742 Replicon plasmid pMK12478
Accession NC_022654
Organism Mycobacterium kansasii ATCC 12478

Toxin (Protein)


Gene name relE Uniprot ID D5P5D7
Locus tag MKAN_RS28340 Protein ID WP_007172405.1
Coordinates 105485..105742 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M1FTM7
Locus tag MKAN_RS28335 Protein ID WP_007172404.1
Coordinates 105204..105488 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKAN_RS28315 100337..101857 - 1521 WP_007172379.1 DUF4226 domain-containing protein -
MKAN_RS29040 102079..102834 - 756 WP_074021258.1 DUF2637 domain-containing protein -
MKAN_RS28325 103663..104358 + 696 WP_007172400.1 ParA family protein -
MKAN_RS29045 104361..105122 + 762 WP_023363524.1 hypothetical protein -
MKAN_RS28335 105204..105488 + 285 WP_007172404.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKAN_RS28340 105485..105742 + 258 WP_007172405.1 Txe/YoeB family addiction module toxin Toxin
MKAN_RS28345 105957..106250 - 294 WP_007172406.1 hypothetical protein -
MKAN_RS28350 106267..107265 - 999 WP_101930848.1 hypothetical protein -
MKAN_RS28355 107977..108546 + 570 WP_007172408.1 hypothetical protein -
MKAN_RS28360 108536..109636 + 1101 WP_007172409.1 tyrosine-type recombinase/integrase -
MKAN_RS28365 109755..109967 + 213 WP_007172410.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..144951 144951


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10156.56 Da        Isoelectric Point: 9.8613

>T30276 WP_007172405.1 NC_022654:105485-105742 [Mycobacterium kansasii ATCC 12478]
VRSINFDPAAWEDFLFWLASDRKTARRITRLIAEIQRNPFAGIGKPEPLKGELSGYWSRRIDDEHRIVYRADDHEIKILK
ARYHY

Download         Length: 258 bp

>T30276 NC_022654:105485-105742 [Mycobacterium kansasii ATCC 12478]
GTGAGAAGCATCAACTTCGATCCCGCCGCGTGGGAGGACTTTCTATTTTGGCTGGCTTCCGACCGCAAAACAGCACGGCG
CATCACCAGACTCATCGCAGAAATCCAGCGCAACCCGTTTGCTGGGATTGGAAAACCAGAACCGCTCAAGGGTGAACTAT
CCGGGTACTGGTCGCGGCGCATCGACGACGAACACCGGATCGTCTACCGCGCAGATGATCACGAAATCAAGATCCTCAAA
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10455.62 Da        Isoelectric Point: 4.3885

>AT30276 WP_007172404.1 NC_022654:105204-105488 [Mycobacterium kansasii ATCC 12478]
MAISASEARQRLFPLLEQVNTDHEPVRITSKAGDAVLMSAADYDSWQETVYLLRSPENARRLMEAVARDNATRPTPGSYT
KSIDELEEMAGGQE

Download         Length: 285 bp

>AT30276 NC_022654:105204-105488 [Mycobacterium kansasii ATCC 12478]
ATGGCTATCAGTGCAAGTGAGGCCCGGCAGCGCCTCTTTCCGCTGCTTGAACAAGTCAACACCGACCACGAGCCTGTGCG
AATTACGTCCAAGGCCGGAGATGCAGTGCTCATGTCGGCCGCTGACTACGATTCGTGGCAAGAAACGGTCTACCTCCTGC
GTTCCCCCGAGAATGCCCGCCGACTCATGGAGGCCGTCGCCCGAGACAACGCCACCCGGCCCACCCCCGGCAGCTACACC
AAGTCGATCGACGAACTCGAGGAGATGGCCGGCGGCCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y0THX2

Antitoxin

Source ID Structure
AlphaFold DB M1FTM7

References