Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 77546..78228 | Replicon | plasmid pMK12478 |
Accession | NC_022654 | ||
Organism | Mycobacterium kansasii ATCC 12478 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A854IDQ2 |
Locus tag | MKAN_RS28190 | Protein ID | WP_040624374.1 |
Coordinates | 77812..78228 (+) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | D5P579 |
Locus tag | MKAN_RS28185 | Protein ID | WP_007172349.1 |
Coordinates | 77546..77809 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MKAN_RS28160 | 72618..74063 | - | 1446 | WP_101930849.1 | type VII secretion protein EccB | - |
MKAN_RS28165 | 74177..75217 | - | 1041 | WP_023363502.1 | C40 family peptidase | - |
MKAN_RS29025 | 75303..76406 | - | 1104 | WP_051404593.1 | hypothetical protein | - |
MKAN_RS28180 | 76470..77444 | - | 975 | WP_023363505.1 | hypothetical protein | - |
MKAN_RS28185 | 77546..77809 | + | 264 | WP_007172349.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
MKAN_RS28190 | 77812..78228 | + | 417 | WP_040624374.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
MKAN_RS28195 | 78510..79772 | - | 1263 | WP_169733147.1 | IS256 family transposase | - |
MKAN_RS28200 | 79984..80565 | + | 582 | WP_007172352.1 | IS607 family transposase | - |
MKAN_RS28205 | 80565..82217 | + | 1653 | WP_040624340.1 | IS607 family element transposase accessory protein TnpB | - |
MKAN_RS29030 | 82323..82461 | + | 139 | Protein_86 | type II toxin-antitoxin system VapC family toxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | eccA5 / esxN | 1..144951 | 144951 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 14879.84 Da Isoelectric Point: 5.4519
>T30274 WP_040624374.1 NC_022654:77812-78228 [Mycobacterium kansasii ATCC 12478]
MIIDSSAIVALIQGEDPYTEQIAAAIAADPSPVMSTANAAECLIVLTNRHGATARTVFDRLRSEINLGFQPFTLEHAIAA
HRAYLHYGKGRHPAALNYGDTMAYATAKLAHEPLIAIGNDFTQTDLEFNGVIGYWPAP
MIIDSSAIVALIQGEDPYTEQIAAAIAADPSPVMSTANAAECLIVLTNRHGATARTVFDRLRSEINLGFQPFTLEHAIAA
HRAYLHYGKGRHPAALNYGDTMAYATAKLAHEPLIAIGNDFTQTDLEFNGVIGYWPAP
Download Length: 417 bp
>T30274 NC_022654:77812-78228 [Mycobacterium kansasii ATCC 12478]
CTGATCATCGACTCTTCCGCGATCGTCGCCCTCATCCAGGGCGAGGACCCCTACACCGAACAGATCGCGGCCGCCATCGC
CGCCGATCCCAGCCCCGTCATGTCCACGGCCAACGCAGCCGAATGCCTCATCGTTCTCACCAACCGACACGGCGCGACCG
CGCGCACCGTCTTCGACCGCCTACGATCCGAAATCAACCTCGGCTTCCAGCCCTTCACCCTCGAACACGCGATCGCCGCC
CACCGCGCCTACCTCCACTACGGAAAAGGCCGCCACCCCGCCGCCCTCAACTACGGCGACACCATGGCCTACGCCACCGC
CAAACTCGCACACGAACCCCTCATCGCCATCGGCAACGACTTCACCCAAACCGACCTCGAATTCAACGGCGTCATCGGCT
ACTGGCCAGCGCCCTAA
CTGATCATCGACTCTTCCGCGATCGTCGCCCTCATCCAGGGCGAGGACCCCTACACCGAACAGATCGCGGCCGCCATCGC
CGCCGATCCCAGCCCCGTCATGTCCACGGCCAACGCAGCCGAATGCCTCATCGTTCTCACCAACCGACACGGCGCGACCG
CGCGCACCGTCTTCGACCGCCTACGATCCGAAATCAACCTCGGCTTCCAGCCCTTCACCCTCGAACACGCGATCGCCGCC
CACCGCGCCTACCTCCACTACGGAAAAGGCCGCCACCCCGCCGCCCTCAACTACGGCGACACCATGGCCTACGCCACCGC
CAAACTCGCACACGAACCCCTCATCGCCATCGGCAACGACTTCACCCAAACCGACCTCGAATTCAACGGCGTCATCGGCT
ACTGGCCAGCGCCCTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9884.20 Da Isoelectric Point: 4.8359
>AT30274 WP_007172349.1 NC_022654:77546-77809 [Mycobacterium kansasii ATCC 12478]
MAFNVKDEEVIRFADELAARLHLPSRIDAIRYALRAQIEVTQSRTANRSAELLDVLKTEIWPLLDDRSPITKTEREQALG
YDTATGV
MAFNVKDEEVIRFADELAARLHLPSRIDAIRYALRAQIEVTQSRTANRSAELLDVLKTEIWPLLDDRSPITKTEREQALG
YDTATGV
Download Length: 264 bp
>AT30274 NC_022654:77546-77809 [Mycobacterium kansasii ATCC 12478]
ATGGCTTTCAACGTGAAAGACGAAGAGGTCATCCGCTTCGCAGACGAGCTCGCCGCGCGCCTCCACCTCCCCAGCCGCAT
CGACGCCATCCGCTACGCCCTGCGAGCCCAGATCGAAGTCACCCAATCCCGCACCGCAAACCGCTCCGCAGAACTGCTCG
ACGTCCTCAAAACCGAGATCTGGCCACTACTGGACGACCGATCCCCAATCACCAAAACCGAACGCGAACAAGCCCTCGGA
TACGACACAGCAACGGGAGTTTGA
ATGGCTTTCAACGTGAAAGACGAAGAGGTCATCCGCTTCGCAGACGAGCTCGCCGCGCGCCTCCACCTCCCCAGCCGCAT
CGACGCCATCCGCTACGCCCTGCGAGCCCAGATCGAAGTCACCCAATCCCGCACCGCAAACCGCTCCGCAGAACTGCTCG
ACGTCCTCAAAACCGAGATCTGGCCACTACTGGACGACCGATCCCCAATCACCAAAACCGAACGCGAACAAGCCCTCGGA
TACGACACAGCAACGGGAGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A854IDQ2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Y0TBQ2 |