Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2278646..2279477 Replicon chromosome
Accession NC_022648
Organism Escherichia coli JJ1886

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag P423_RS11855 Protein ID WP_000854815.1
Coordinates 2279103..2279477 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag P423_RS11850 Protein ID WP_001280918.1
Coordinates 2278646..2279014 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P423_RS11805 2273732..2274478 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
P423_RS11810 2274561..2274911 + 351 Protein_2246 hypothetical protein -
P423_RS11815 2274927..2275337 + 411 WP_000846703.1 hypothetical protein -
P423_RS11820 2275558..2276376 + 819 WP_001542275.1 DUF945 domain-containing protein -
P423_RS11830 2276718..2277191 + 474 WP_001542276.1 antirestriction protein -
P423_RS11835 2277207..2277683 + 477 WP_001186200.1 RadC family protein -
P423_RS11840 2277746..2277967 + 222 WP_000692345.1 DUF987 domain-containing protein -
P423_RS11845 2277986..2278630 + 645 WP_000086752.1 hypothetical protein -
P423_RS11850 2278646..2279014 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
P423_RS11855 2279103..2279477 + 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
P423_RS11860 2279474..2279668 + 195 WP_000988600.1 hypothetical protein -
P423_RS30410 2279681..2279794 + 114 WP_001161660.1 DUF957 domain-containing protein -
P423_RS29975 2280083..2280256 - 174 WP_032082634.1 transposase domain-containing protein -
P423_RS29980 2280283..2280465 + 183 WP_001296208.1 hypothetical protein -
P423_RS11880 2280566..2280895 - 330 WP_000450409.1 DUF496 family protein -
P423_RS11885 2281067..2282125 - 1059 WP_001200889.1 FUSC family protein -
P423_RS11890 2282323..2282796 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
P423_RS11895 2282915..2284081 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T30249 WP_000854815.1 NC_022648:2279103-2279477 [Escherichia coli JJ1886]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T30249 NC_022648:2279103-2279477 [Escherichia coli JJ1886]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT30249 WP_001280918.1 NC_022648:2278646-2279014 [Escherichia coli JJ1886]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT30249 NC_022648:2278646-2279014 [Escherichia coli JJ1886]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References