Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 2218977..2219602 Replicon chromosome
Accession NC_022604
Organism Staphylococcus aureus subsp. aureus Z172

Toxin (Protein)


Gene name doc Uniprot ID A0A380FZ43
Locus tag SAZ172_RS11415 Protein ID WP_001179607.1
Coordinates 2218977..2219372 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A380FXS4
Locus tag SAZ172_RS11420 Protein ID WP_000258939.1
Coordinates 2219372..2219602 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAZ172_RS11375 2214532..2214972 - 441 Protein_2168 GNAT family N-acetyltransferase -
SAZ172_RS11380 2214947..2215198 - 252 WP_002505594.1 hypothetical protein -
SAZ172_RS11385 2215195..2215830 - 636 Protein_2170 aminoglycoside 6-adenylyltransferase -
SAZ172_RS11390 2216045..2216767 - 723 WP_001043218.1 hypothetical protein -
SAZ172_RS11395 2216876..2217676 - 801 WP_000686449.1 metallophosphoesterase -
SAZ172_RS11400 2217680..2218174 - 495 WP_000280790.1 hypothetical protein -
SAZ172_RS11405 2218231..2218500 - 270 WP_000755772.1 hypothetical protein -
SAZ172_RS11410 2218484..2218675 - 192 WP_032605691.1 hypothetical protein -
SAZ172_RS11415 2218977..2219372 - 396 WP_001179607.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
SAZ172_RS11420 2219372..2219602 - 231 WP_000258939.1 addiction module antitoxin Antitoxin
SAZ172_RS11425 2219778..2220299 - 522 WP_000639078.1 metallophosphoesterase -
SAZ172_RS11430 2220299..2220949 - 651 WP_000411528.1 hypothetical protein -
SAZ172_RS11435 2220949..2221266 - 318 WP_001807410.1 hypothetical protein -
SAZ172_RS11440 2221259..2221984 - 726 WP_000197304.1 metallophosphoesterase -
SAZ172_RS11445 2221984..2222205 - 222 WP_000829423.1 hypothetical protein -
SAZ172_RS16595 2222225..2222410 - 186 WP_129760514.1 hypothetical protein -
SAZ172_RS11450 2222394..2222936 - 543 WP_000858632.1 hypothetical protein -
SAZ172_RS11455 2222951..2223223 - 273 WP_000691100.1 hypothetical protein -
SAZ172_RS11460 2223249..2223404 - 156 WP_000792995.1 transcriptional regulator -
SAZ172_RS16770 2223518..2223685 - 168 WP_000312832.1 hypothetical protein -
SAZ172_RS11465 2223701..2223886 - 186 WP_001187008.1 hypothetical protein -
SAZ172_RS11470 2223871..2224050 - 180 WP_000401832.1 hypothetical protein -
SAZ172_RS11475 2224064..2224546 - 483 WP_000833764.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aac(6')-aph(2'') / aph(3')-III - 2181190..2255877 74687


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15035.51 Da        Isoelectric Point: 9.4574

>T30221 WP_001179607.1 NC_022604:c2219372-2218977 [Staphylococcus aureus subsp. aureus Z172]
MQNIKYLTEKQVIAINVKAIQELSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFFNANKR
TAFTSMVIFLKLNKINFNCTQDEAVQFTLKVVEDKTLTLEDIADWIKRHCK

Download         Length: 396 bp

>T30221 NC_022604:c2219372-2218977 [Staphylococcus aureus subsp. aureus Z172]
ATGCAAAACATTAAATATTTAACTGAAAAACAAGTAATTGCCATTAATGTAAAAGCAATTCAAGAACTCTCACCTAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAGGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTTGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCGGCTTTTATATACAGAAATATAGCTCAAAAACATGCATTCTTTAATGCGAATAAGAGA
ACAGCTTTTACATCTATGGTTATTTTCTTGAAGTTAAATAAGATTAATTTTAATTGTACTCAAGACGAAGCGGTACAATT
TACTTTAAAAGTGGTAGAGGATAAAACTCTTACACTTGAAGATATTGCAGATTGGATCAAAAGGCATTGTAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8617.73 Da        Isoelectric Point: 4.4501

>AT30221 WP_000258939.1 NC_022604:c2219602-2219372 [Staphylococcus aureus subsp. aureus Z172]
MVTTRKLRRAGNSSVVSVPTEVIAALGVTNGDNLKFNIEDNKVTIEKEVNEDEEFFKLLDETFTEYNQALRKLVDI

Download         Length: 231 bp

>AT30221 NC_022604:c2219602-2219372 [Staphylococcus aureus subsp. aureus Z172]
ATGGTTACTACAAGAAAACTAAGAAGAGCTGGCAATAGTTCAGTTGTTTCTGTACCAACAGAAGTGATCGCAGCACTCGG
AGTTACAAATGGTGACAATCTTAAATTTAATATTGAAGATAATAAAGTAACCATTGAAAAGGAGGTAAACGAAGACGAAG
AGTTTTTCAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTCTGAGAAAGTTGGTTGACATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380FZ43

Antitoxin

Source ID Structure
AlphaFold DB A0A380FXS4

References