Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 913697..914202 Replicon chromosome
Accession NC_022604
Organism Staphylococcus aureus subsp. aureus Z172

Toxin (Protein)


Gene name TscT Uniprot ID A0A0C6E6D5
Locus tag SAZ172_RS04480 Protein ID WP_001103946.1
Coordinates 913909..914202 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IA75
Locus tag SAZ172_RS04475 Protein ID WP_001058492.1
Coordinates 913697..913906 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAZ172_RS04440 909214..910434 - 1221 WP_000264182.1 site-specific integrase -
SAZ172_RS04445 910522..911250 - 729 WP_000733773.1 staphylococcal enterotoxin type K -
SAZ172_RS04450 911274..912002 - 729 WP_001033317.1 staphylococcal enterotoxin type Q -
SAZ172_RS04455 912177..912911 - 735 WP_000142630.1 helix-turn-helix domain-containing protein -
SAZ172_RS04460 913061..913273 + 213 WP_001063624.1 helix-turn-helix transcriptional regulator -
SAZ172_RS04465 913274..913546 + 273 WP_001138298.1 helix-turn-helix domain-containing protein -
SAZ172_RS04470 913558..913704 + 147 WP_000784885.1 hypothetical protein -
SAZ172_RS04475 913697..913906 + 210 WP_001058492.1 hypothetical protein Antitoxin
SAZ172_RS04480 913909..914202 + 294 WP_001103946.1 DUF1474 family protein Toxin
SAZ172_RS04485 914290..915159 + 870 WP_001002691.1 primase alpha helix C-terminal domain-containing protein -
SAZ172_RS04490 915176..916633 + 1458 WP_000432707.1 virulence-associated E family protein -
SAZ172_RS04495 916935..917297 + 363 WP_001039172.1 hypothetical protein -
SAZ172_RS04500 917299..917583 + 285 WP_000998180.1 hypothetical protein -
SAZ172_RS04505 917580..918221 + 642 WP_001019783.1 hypothetical protein -
SAZ172_RS04510 918670..919011 + 342 WP_001190616.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 903858..921325 17467


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-97)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11590.08 Da        Isoelectric Point: 4.9594

>T30213 WP_001103946.1 NC_022604:913909-914202 [Staphylococcus aureus subsp. aureus Z172]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA

Download         Length: 294 bp

>T30213 NC_022604:913909-914202 [Staphylococcus aureus subsp. aureus Z172]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGCGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGATCAAAGCGAAAGTAACGCATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8238.28 Da        Isoelectric Point: 4.3718

>AT30213 WP_001058492.1 NC_022604:913697-913906 [Staphylococcus aureus subsp. aureus Z172]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT30213 NC_022604:913697-913906 [Staphylococcus aureus subsp. aureus Z172]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6E6D5

Antitoxin

Source ID Structure
AlphaFold DB X5IA75

References