Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 896580..897057 Replicon chromosome
Accession NC_022604
Organism Staphylococcus aureus subsp. aureus Z172

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag SAZ172_RS04335 Protein ID WP_000052078.1
Coordinates 896580..896768 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAZ172_RS04340 Protein ID WP_001059690.1
Coordinates 896797..897057 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAZ172_RS04305 892099..892785 + 687 WP_001548082.1 thermonuclease family protein -
SAZ172_RS04310 893089..894261 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -
SAZ172_RS04315 894474..894674 + 201 WP_001059082.1 cold-shock protein -
SAZ172_RS04320 895171..895389 - 219 WP_000005886.1 hypothetical protein -
SAZ172_RS04325 895451..895735 - 285 WP_001004395.1 hypothetical protein -
SAZ172_RS04330 895823..896392 - 570 WP_001106654.1 hypothetical protein -
SAZ172_RS04335 896580..896768 - 189 WP_000052078.1 hypothetical protein Toxin
SAZ172_RS04340 896797..897057 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAZ172_RS04345 897398..897601 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAZ172_RS04350 897598..897834 - 237 WP_000368687.1 hypothetical protein -
SAZ172_RS04355 898059..898640 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
SAZ172_RS04360 898713..899330 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SAZ172_RS04365 899485..899979 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAZ172_RS04370 900378..900800 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAZ172_RS04375 900948..901664 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 893089..894261 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T30212 WP_000052078.1 NC_022604:c896768-896580 [Staphylococcus aureus subsp. aureus Z172]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T30212 NC_022604:c896768-896580 [Staphylococcus aureus subsp. aureus Z172]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT30212 WP_001059690.1 NC_022604:c897057-896797 [Staphylococcus aureus subsp. aureus Z172]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT30212 NC_022604:c897057-896797 [Staphylococcus aureus subsp. aureus Z172]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References