Detailed information of TA system TA030207

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 2433778..2434815
• Replicon: chromosome
• Accession: NC_022576
• Organism: Candidatus Symbiobacter mobilis CR

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: CENROD_RS09955
• Protein ID: WP_022775579.1
• Coordinates: 2433778..2434350 (-)
• Length: 191 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: U5N9M9
• Locus tag: CENROD_RS09960
• Protein ID: WP_022775583.1
• Coordinates: 2434351..2434815 (-)
• Length: 155 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CENROD_RS09940	2429250..2429906	-	657	WP_022775572.1	adenylate kinase	-
CENROD_RS09950	2430249..2433647	-	3399	WP_022775575.1	type I-F CRISPR-associated helicase Cas3	-
CENROD_RS09955	2433778..2434350	-	573	WP_022775579.1	PIN domain-containing protein	Toxin
CENROD_RS09960	2434351..2434815	-	465	WP_022775583.1	helix-turn-helix domain-containing protein	Antitoxin
CENROD_RS13675	2434959..2435215	-	257	Protein_1986	IS21 family transposase	-
CENROD_RS09970	2435553..2436386	-	834	WP_041194602.1	IS5 family transposase	-
CENROD_RS09975	2437934..2438500	-	567	WP_022775596.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
CENROD_RS09980	2438505..2439542	-	1038	WP_022775599.1	type I-F CRISPR-associated protein Csy3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2435553..2436386	833

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-114)

Antitoxin

• SinI-like, DNA-binding domain (83-130)

Sequences

Toxin

Protein

• Length: 191 a.a.
• Molecular weight: 21783.94 Da
• Isoelectric Point: 6.2916

>T30207 WP_022775579.1 NC_022576:c2434350-2433778 [Candidatus Symbiobacter mobilis CR]
MSSNFTVIYDACVLYPAPLRDLLMRLALTDLYRARWTDMIHDEWMRNVLKQRPDLQAEDLERTRSLMNAHVRDSLVTGFE
HLIPSVELPDTDDRHVVAAAIHGGASLIVTFNLKDFPPDQLKRYNLAAQHPDDFIFDLLDLHAARVCEAAANHRRSLKNP
PKTVDEYLDTLLKQGLTQTVGQLREWKVAI

Nucleotide

• Length: 573 bp

>T30207 NC_022576:c2434350-2433778 [Candidatus Symbiobacter mobilis CR]
ATGAGTTCGAACTTCACCGTCATCTACGACGCGTGCGTGCTCTATCCGGCACCGTTACGCGACCTGCTGATGCGTCTGGC
ACTGACCGATCTGTACCGGGCGCGTTGGACGGACATGATCCACGACGAGTGGATGCGTAACGTTCTGAAGCAGCGGCCAG
ATCTGCAGGCCGAAGACCTGGAGCGGACGCGGTCGCTGATGAATGCCCACGTCCGCGACAGTCTGGTCACCGGCTTCGAG
CATCTGATCCCGTCCGTCGAGTTGCCGGACACCGATGACCGACATGTGGTTGCCGCCGCCATTCACGGCGGCGCCAGCCT
GATCGTGACCTTCAACCTGAAGGATTTCCCGCCGGACCAGCTCAAGCGCTACAACCTGGCCGCCCAGCATCCCGACGACT
TCATCTTCGATCTACTAGATCTGCATGCAGCCCGAGTCTGCGAGGCGGCTGCCAACCATCGCCGGTCGCTGAAGAACCCG
CCCAAGACGGTTGATGAATACCTGGACACGCTGCTCAAGCAGGGGCTGACACAGACTGTCGGCCAGTTGCGGGAGTGGAA
GGTAGCGATCTGA

Antitoxin

Protein

• Length: 155 a.a.
• Molecular weight: 17071.41 Da
• Isoelectric Point: 6.1400

>AT30207 WP_022775583.1 NC_022576:c2434815-2434351 [Candidatus Symbiobacter mobilis CR]
MTTLSPTHSLPTAEEVAIARESGRALSAFLQTRAETQQIEIFDDRGASHPVRVPVSALRLLVDVLTEIGEGNAVSIIPIH
AELTTQDAADVLNVSRPFLVQLLEHGEIPFHKIGTHRRVRYQDVIAYKERIDAERSKALHALTEQAQALKMGYE

Nucleotide

• Length: 465 bp

>AT30207 NC_022576:c2434815-2434351 [Candidatus Symbiobacter mobilis CR]
ATGACCACACTCTCTCCCACCCATTCGTTGCCGACGGCCGAAGAAGTTGCCATCGCCCGCGAGAGCGGCCGGGCGCTGTC
CGCATTCCTGCAGACCCGTGCGGAAACCCAGCAGATCGAGATCTTCGACGACAGGGGAGCGTCCCATCCGGTCCGCGTCC
CGGTGTCGGCGCTGCGGCTGCTCGTGGACGTCCTGACCGAAATCGGTGAGGGCAACGCGGTCAGCATCATCCCGATCCAC
GCCGAACTGACGACCCAGGACGCAGCAGACGTGCTCAACGTCTCGCGACCGTTCCTTGTGCAGTTGCTGGAGCACGGCGA
GATTCCGTTTCACAAAATCGGAACGCACCGTCGCGTCCGCTACCAAGACGTGATCGCGTACAAGGAGCGGATCGACGCTG
AGCGCAGCAAGGCCCTCCATGCACTGACCGAGCAAGCCCAGGCGCTCAAGATGGGGTACGAATGA

Structures

Antitoxin

• AlphaFold DB: U5N9M9