Detailed information of TA system TA030206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 2394867..2395276
• Replicon: chromosome
• Accession: NC_022576
• Organism: Candidatus Symbiobacter mobilis CR

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CENROD_RS13220
• Protein ID: WP_081699874.1
• Coordinates: 2394867..2395055 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CENROD_RS13225
• Protein ID: WP_022775466.1
• Coordinates: 2395058..2395276 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CENROD_RS09770	2390024..2390752	+	729	WP_202961198.1	RES family NAD+ phosphorylase	-
CENROD_RS13210	2390924..2391757	-	834	WP_081699951.1	IS5 family transposase	-
CENROD_RS09780	2391838..2393292	+	1455	WP_041193513.1	hypothetical protein	-
CENROD_RS09785	2393499..2393705	-	207	WP_022775452.1	hypothetical protein	-
CENROD_RS12645	2393702..2394025	-	324	WP_151194616.1	addiction module protein	-
CENROD_RS13215	2394133..2394624	+	492	WP_022775459.1	type II toxin-antitoxin system VapC family toxin	-
CENROD_RS13670	2394605..2394820	+	216	WP_022775463.1	hypothetical protein	-
CENROD_RS13220	2394867..2395055	+	189	WP_081699874.1	type II toxin-antitoxin system HicA family toxin	Toxin
CENROD_RS13225	2395058..2395276	+	219	WP_022775466.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CENROD_RS09800	2395609..2396202	+	594	WP_022775476.1	response regulator transcription factor	-
CENROD_RS09805	2396251..2398983	-	2733	WP_022775477.1	alanine--tRNA ligase	-
CENROD_RS09810	2399028..2399486	-	459	WP_022775478.1	RidA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2390924..2391757	833

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-62)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7003.15 Da
• Isoelectric Point: 10.9293

>T30206 WP_081699874.1 NC_022576:2394867-2395055 [Candidatus Symbiobacter mobilis CR]
MKVPELIRITEEDRWFLVRQSGRHRQFHHPSKSGIVTIAGKLSIDVPPGTLNSVLKQAGLKE

Nucleotide

• Length: 189 bp

>T30206 NC_022576:2394867-2395055 [Candidatus Symbiobacter mobilis CR]
ATGAAAGTTCCGGAATTGATACGGATTACTGAGGAGGATAGATGGTTCTTGGTACGCCAAAGTGGCAGACATCGCCAATT
TCACCATCCAAGTAAATCAGGAATCGTTACTATTGCAGGAAAACTCAGCATTGACGTGCCACCCGGAACCTTGAATAGTG
TACTCAAGCAAGCTGGCTTAAAGGAGTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 7987.23 Da
• Isoelectric Point: 4.3344

>AT30206 WP_022775466.1 NC_022576:2395058-2395276 [Candidatus Symbiobacter mobilis CR]
MRYMVVVEKGETSYGCFVPDIPGCVAVGETENEVVSLIQEAIRFHLEDLRFEGQPIPMPASKSKFIEVALNA

Nucleotide

• Length: 219 bp

>AT30206 NC_022576:2395058-2395276 [Candidatus Symbiobacter mobilis CR]
ATGCGATATATGGTAGTAGTTGAAAAAGGTGAGACAAGTTATGGTTGTTTTGTTCCAGACATTCCAGGCTGTGTCGCCGT
TGGCGAAACTGAAAATGAAGTTGTCAGCCTTATTCAAGAGGCTATTCGATTTCACTTGGAAGACTTGCGATTCGAAGGAC
AACCAATTCCGATGCCTGCATCCAAAAGCAAATTCATTGAAGTTGCTTTGAATGCCTAA