Detailed information of TA system TA030198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PrlF(antitoxin)
• Location: 1458073..1458442
• Replicon: chromosome
• Accession: NC_022576
• Organism: Candidatus Symbiobacter mobilis CR

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: CENROD_RS14060
• Protein ID: WP_202961180.1
• Coordinates: 1458293..1458442 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: U5N7C7
• Locus tag: CENROD_RS06000
• Protein ID: WP_022772641.1
• Coordinates: 1458073..1458300 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CENROD_RS05985	1453789..1454736	+	948	WP_022772630.1	flagellar assembly peptidoglycan hydrolase FlgJ	-
CENROD_RS05990	1454733..1456664	+	1932	WP_022772633.1	flagellar hook-associated protein FlgK	-
CENROD_RS05995	1456680..1457927	+	1248	WP_022772637.1	flagellar hook-associated protein FlgL	-
CENROD_RS06000	1458073..1458300	+	228	WP_022772641.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
CENROD_RS14060	1458293..1458442	+	150	WP_202961180.1	hypothetical protein	Toxin
CENROD_RS06010	1458705..1460285	+	1581	WP_022772644.1	site-specific DNA-methyltransferase	-
CENROD_RS06015	1460288..1460575	+	288	WP_022772647.1	hypothetical protein	-
CENROD_RS06020	1460572..1460781	+	210	WP_022772650.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• PrlF antitoxin (5-52)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5212.20 Da
• Isoelectric Point: 9.4175

>T30198 WP_202961180.1 NC_022576:1458293-1458442 [Candidatus Symbiobacter mobilis CR]
VTDERGQVVLAMITSAKNAPWPLDIHIKNLAVAGLPAPSVVRCKLFTLG

Nucleotide

• Length: 150 bp

>T30198 NC_022576:1458293-1458442 [Candidatus Symbiobacter mobilis CR]
GTGACTGATGAGCGTGGCCAAGTCGTGTTAGCGATGATCACCTCGGCCAAGAATGCCCCCTGGCCGCTGGACATCCACAT
CAAAAACTTGGCCGTAGCTGGGCTACCGGCACCCTCGGTGGTTCGATGCAAGCTGTTCACGCTGGGATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8224.20 Da
• Isoelectric Point: 4.0932

>AT30198 WP_022772641.1 NC_022576:1458073-1458300 [Candidatus Symbiobacter mobilis CR]
MTAIAKITAQGQTTIPADVRQALRVGSGDLLAWEMLEDGVACVRRVPRIDSDYLQAIEGTLTEWNSAADEEAYRD

Nucleotide

• Length: 228 bp

>AT30198 NC_022576:1458073-1458300 [Candidatus Symbiobacter mobilis CR]
ATGACTGCCATCGCCAAAATCACCGCCCAAGGCCAAACCACCATTCCGGCCGATGTACGCCAGGCCCTGCGTGTGGGGTC
GGGCGACTTGCTAGCCTGGGAAATGCTGGAAGACGGCGTGGCGTGCGTGCGCCGCGTTCCGCGCATCGATTCGGATTACC
TACAAGCCATCGAAGGCACGCTGACCGAATGGAATTCGGCGGCAGACGAGGAGGCCTATCGTGACTGA

Structures

Antitoxin

• AlphaFold DB: U5N7C7