Detailed information of TA system TA030195

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 936144..936775
• Replicon: chromosome
• Accession: NC_022576
• Organism: Candidatus Symbiobacter mobilis CR

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: U5N9Q7
• Locus tag: CENROD_RS03855
• Protein ID: WP_022771793.1
• Coordinates: 936144..936545 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U5N9W3
• Locus tag: CENROD_RS03860
• Protein ID: WP_022771794.1
• Coordinates: 936542..936775 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CENROD_RS03840	932346..932846	-	501	WP_022771790.1	DUF3368 domain-containing protein	-
CENROD_RS03845	932836..933090	-	255	WP_022771791.1	UPF0175 family protein	-
CENROD_RS03850	933169..936030	-	2862	WP_022771792.1	DUF1156 domain-containing protein	-
CENROD_RS03855	936144..936545	-	402	WP_022771793.1	type II toxin-antitoxin system VapC family toxin	Toxin
CENROD_RS03860	936542..936775	-	234	WP_022771794.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CENROD_RS03865	936922..937548	-	627	WP_022771795.1	DUF3780 domain-containing protein	-
CENROD_RS03870	937551..940736	-	3186	WP_022771796.1	DUF499 domain-containing protein	-
CENROD_RS03875	940776..940991	-	216	WP_041194020.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14434.77 Da
• Isoelectric Point: 6.9469

>T30195 WP_022771793.1 NC_022576:c936545-936144 [Candidatus Symbiobacter mobilis CR]
MILLDTNICIYIINAKPAGVLARFQQYRLGDIGLCSVVAAELAFGVAKSGSARNRQALEMFLAPLSILPFDTAAVWTYGD
LRADLERRGTPIGSLDTMIAAHALSQNALLITNNTREFAKVPGLQLDNWFVAP

Nucleotide

• Length: 402 bp

>T30195 NC_022576:c936545-936144 [Candidatus Symbiobacter mobilis CR]
ATGATCCTGCTTGACACCAACATTTGCATCTACATCATCAATGCCAAACCAGCAGGGGTGCTGGCGCGTTTTCAGCAGTA
CCGGCTGGGCGACATTGGGCTGTGCAGTGTGGTTGCTGCGGAGCTGGCGTTTGGTGTCGCCAAAAGCGGCTCGGCACGCA
ACCGCCAAGCGCTGGAGATGTTTCTGGCCCCTTTGAGCATTTTGCCGTTCGATACTGCAGCCGTTTGGACCTATGGCGAC
CTGCGCGCTGACCTGGAGCGCCGTGGCACCCCCATTGGCTCGCTAGACACCATGATTGCCGCGCACGCCCTGAGCCAAAA
CGCGCTGCTGATCACCAACAACACCCGTGAGTTTGCCAAGGTGCCAGGTTTGCAACTGGACAACTGGTTTGTTGCGCCTT
GA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8524.81 Da
• Isoelectric Point: 7.0091

>AT30195 WP_022771794.1 NC_022576:c936775-936542 [Candidatus Symbiobacter mobilis CR]
MNTARLFQSGRSQAVRLPKEYRFVGTEVMVKHFGNGVLLLPVDDPWQTLAAGLAAFEPGFVLTREQPDAQIRAEIAP

Nucleotide

• Length: 234 bp

>AT30195 NC_022576:c936775-936542 [Candidatus Symbiobacter mobilis CR]
ATGAACACCGCACGCCTTTTTCAATCCGGCCGCAGCCAGGCCGTTCGCTTGCCCAAAGAATACCGGTTTGTCGGCACCGA
AGTGATGGTCAAACATTTTGGCAATGGTGTATTGCTGCTGCCGGTAGATGACCCGTGGCAGACGTTGGCGGCTGGACTAG
CGGCCTTTGAGCCCGGTTTTGTCTTGACCCGCGAGCAACCCGACGCGCAGATTCGCGCTGAGATTGCCCCATGA

Structures

Toxin

• AlphaFold DB: U5N9Q7

Antitoxin

• AlphaFold DB: U5N9W3