30194

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 552627..554137 Replicon chromosome
Accession NC_022576
Organism Candidatus Symbiobacter mobilis CR

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag CENROD_RS02260 Protein ID WP_081699793.1
Coordinates 553223..554137 (+) Length 305 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID U5N531
Locus tag CENROD_RS02255 Protein ID WP_022771452.1
Coordinates 552627..553226 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CENROD_RS13450 547964..548545 - 582 WP_202961173.1 acyltransferase -
CENROD_RS12955 548651..549973 - 1323 WP_187292320.1 lipopolysaccharide biosynthesis protein -
CENROD_RS02240 549954..550961 - 1008 WP_022771448.1 NAD-dependent epimerase -
CENROD_RS02245 551470..551853 + 384 WP_022771450.1 type II toxin-antitoxin system RelE/ParE family toxin -
CENROD_RS02250 551858..552208 + 351 WP_022771451.1 XRE family transcriptional regulator -
CENROD_RS02255 552627..553226 + 600 WP_022771452.1 AbiEi antitoxin N-terminal domain-containing protein Antitoxin
CENROD_RS02260 553223..554137 + 915 WP_081699793.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CENROD_RS02265 554175..554789 - 615 WP_022771454.1 hypothetical protein -
CENROD_RS02270 555128..555511 - 384 WP_022771456.1 AAA family ATPase -
CENROD_RS13810 555616..555816 - 201 WP_022771457.1 nucleoside-diphosphate sugar epimerase -
CENROD_RS13815 555859..556044 - 186 WP_022771458.1 NAD-dependent epimerase/dehydratase family protein -
CENROD_RS02280 556465..557472 - 1008 WP_022771460.1 Rpn family recombination-promoting nuclease/putative transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-261)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-51)


Sequences

Toxin        


Download         Length: 305 a.a.        Molecular weight: 34363.29 Da        Isoelectric Point: 6.6116

>T30194 WP_081699793.1 NC_022576:553223-554137 [Candidatus Symbiobacter mobilis CR]
MNQRNTAASVRARLLTRARETRQDFNLVLTRYTLERLLYRLSVSHHADQFLLKGALLFDLWFDIPHRPTRDADLLGFGSA
ELPHLEAVFKDICAMETDDGVTFRPDTVHAAEIRKQANYAGVRVTLLGLIDGARCPIQVDIGFGDAVTPGPEDVQYPVML
PEFAAPKLRVYPRYTVVAEKLEALVSLGIANSRMKDYFDLWILSRYTEFDGDTLRRAIRATFDRRKTMLPLDTPFGLTDA
FAQDAQKQRQWQAFLGKNRLEALHLEDIVASLRDFLLPIIAAANVDADYSQHWPSGGLWSSVVG

Download         Length: 915 bp

>T30194 NC_022576:553223-554137 [Candidatus Symbiobacter mobilis CR]
ATGAACCAGCGCAACACGGCTGCTTCGGTGCGGGCGCGCCTGCTCACCCGCGCCCGCGAGACCCGGCAAGACTTCAATCT
GGTCTTGACCCGCTACACCCTTGAACGCCTGCTGTACCGGCTCAGTGTCTCGCATCATGCCGACCAGTTCCTGCTGAAAG
GCGCGCTGTTGTTCGACTTGTGGTTCGATATTCCGCATCGACCGACGCGGGACGCGGACTTGCTGGGTTTTGGTTCGGCC
GAGTTGCCGCACCTCGAGGCGGTCTTCAAGGACATCTGCGCGATGGAGACTGATGACGGGGTGACGTTTCGACCGGACAC
TGTCCATGCGGCGGAGATTCGCAAGCAGGCCAACTATGCTGGCGTGCGCGTGACCTTACTTGGACTGATCGATGGAGCAC
GCTGCCCGATTCAGGTCGACATCGGCTTCGGCGATGCCGTCACACCAGGGCCGGAAGATGTCCAGTACCCCGTGATGCTA
CCGGAGTTCGCGGCGCCGAAACTGCGCGTCTATCCGCGCTACACCGTGGTGGCAGAAAAGCTGGAGGCGTTGGTCTCGCT
CGGCATCGCCAACAGCCGAATGAAGGATTACTTCGACCTTTGGATCTTGTCGCGGTACACCGAATTTGACGGCGACACCC
TGCGACGTGCGATTCGGGCAACCTTCGATCGACGCAAGACGATGTTGCCCCTGGACACCCCCTTTGGCCTGACGGATGCT
TTTGCGCAAGATGCGCAAAAGCAGAGGCAGTGGCAGGCGTTTTTGGGAAAGAACAGACTCGAAGCGCTGCACCTGGAGGA
CATCGTGGCATCACTTCGAGATTTTCTGCTCCCAATCATCGCGGCAGCGAACGTTGATGCCGACTACTCGCAACACTGGC
CATCTGGCGGACTCTGGTCATCAGTGGTGGGGTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22155.67 Da        Isoelectric Point: 9.2871

>AT30194 WP_022771452.1 NC_022576:552627-553226 [Candidatus Symbiobacter mobilis CR]
METSQQTILNLAAQRGLIRPCDLDARGLPSVALTRLVRQGLLTRVGRGLYACPDRSISEHGSLAEVARKHPQAIVCLLSA
LRVNDLTTQSPFEVWVAIPNKARAPKMDYPPLRIVRFSGAALTDGIDEHQIDGATVRVTNVARTVADCFKFRNKIGIDVG
MEALQEAWHTKRVSMDELWRYATLCRVANVMRPYMESLS

Download         Length: 600 bp

>AT30194 NC_022576:552627-553226 [Candidatus Symbiobacter mobilis CR]
ATGGAAACTTCGCAGCAGACCATTCTGAATCTCGCCGCCCAGCGCGGTCTCATCCGCCCGTGCGATCTCGATGCGCGGGG
TCTGCCCAGTGTCGCCCTCACGCGGCTGGTTCGGCAGGGGCTGCTCACCCGTGTGGGTCGCGGTCTGTATGCCTGTCCTG
ATCGCAGCATATCTGAGCACGGCTCCCTGGCGGAGGTGGCACGCAAACACCCGCAAGCCATCGTCTGCCTGCTGTCGGCT
CTACGGGTGAACGATCTCACCACGCAGTCACCGTTCGAGGTCTGGGTCGCCATTCCCAACAAAGCGCGTGCGCCGAAGAT
GGATTACCCACCGCTGCGCATCGTTCGCTTCTCAGGTGCCGCGCTGACGGATGGAATTGACGAGCACCAGATCGATGGCG
CGACTGTGCGTGTAACCAACGTCGCACGTACCGTGGCCGATTGCTTCAAGTTTCGCAACAAGATCGGCATAGATGTTGGG
ATGGAAGCGCTACAAGAGGCATGGCATACCAAACGCGTGAGCATGGACGAACTCTGGCGCTATGCCACGCTGTGTCGCGT
GGCCAATGTAATGCGCCCTTACATGGAAAGCCTGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U5N531

References