Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4923042..4923558 Replicon chromosome
Accession NC_022566
Organism Klebsiella pneumoniae CG43

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag D364_RS24275 Protein ID WP_004178374.1
Coordinates 4923274..4923558 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag D364_RS24270 Protein ID WP_002886901.1
Coordinates 4923042..4923284 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D364_RS24255 4919070..4919810 + 741 WP_004186692.1 KDGP aldolase family protein -
D364_RS24260 4919877..4921031 + 1155 WP_004210635.1 lactonase family protein -
D364_RS24265 4921054..4922964 + 1911 WP_004152270.1 BglG family transcription antiterminator -
D364_RS24270 4923042..4923284 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D364_RS24275 4923274..4923558 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D364_RS24280 4923562..4924026 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
D364_RS24285 4924268..4926406 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
D364_RS24295 4926763..4927506 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
D364_RS27680 4927509..4927682 - 174 WP_004210630.1 hypothetical protein -
D364_RS24305 4927767..4928075 + 309 WP_004210629.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T30189 WP_004178374.1 NC_022566:4923274-4923558 [Klebsiella pneumoniae CG43]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T30189 NC_022566:4923274-4923558 [Klebsiella pneumoniae CG43]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT30189 WP_002886901.1 NC_022566:4923042-4923284 [Klebsiella pneumoniae CG43]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT30189 NC_022566:4923042-4923284 [Klebsiella pneumoniae CG43]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References