Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2198755..2199314 Replicon chromosome
Accession NC_022543
Organism Vibrio nigripulchritudo

Toxin (Protein)


Gene name relE Uniprot ID U4KJ59
Locus tag VIBNI_RS28535 Protein ID WP_022562210.1
Coordinates 2199036..2199314 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U4DQE1
Locus tag VIBNI_RS28530 Protein ID WP_004404015.1
Coordinates 2198755..2199039 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VIBNI_RS28510 2194355..2195389 + 1035 WP_004404026.1 iron ABC transporter permease -
VIBNI_RS28515 2195386..2196363 + 978 WP_022562207.1 iron chelate uptake ABC transporter family permease subunit -
VIBNI_RS28520 2196368..2197165 + 798 WP_022562208.1 ATP-binding cassette domain-containing protein -
VIBNI_RS28525 2197415..2198248 + 834 WP_022562209.1 inositol monophosphatase -
VIBNI_RS28530 2198755..2199039 + 285 WP_004404015.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VIBNI_RS28535 2199036..2199314 + 279 WP_022562210.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
VIBNI_RS28540 2199364..2199648 - 285 WP_004404008.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VIBNI_RS29090 2199729..2200373 - 645 WP_022562211.1 DUF998 domain-containing protein -
VIBNI_RS28545 2200526..2201281 - 756 WP_022562212.1 uroporphyrinogen-III C-methyltransferase -
VIBNI_RS28550 2201334..2202143 - 810 WP_004403999.1 formate/nitrite transporter family protein -
VIBNI_RS28555 2202255..2202587 - 333 WP_004403996.1 nitrite reductase small subunit NirD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-72)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10851.56 Da        Isoelectric Point: 4.4400

>T30164 WP_022562210.1 NC_022543:2199036-2199314 [Vibrio nigripulchritudo]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDSLIEAKIENLLEQPLMGVQRNGIRGRLLIIPEVSIIVPYWVEGEVIRIL
RVLHQKQKFPTD

Download         Length: 279 bp

>T30164 NC_022543:2199036-2199314 [Vibrio nigripulchritudo]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTGTATGACTTCAATCCTGATGCAGC
AGAGAAAACCGACAGCCTCATTGAAGCAAAAATAGAAAACTTGCTTGAGCAACCTCTTATGGGCGTGCAAAGAAACGGAA
TCCGTGGACGTTTACTCATTATTCCTGAGGTATCAATAATCGTACCGTACTGGGTTGAAGGCGAAGTTATCCGCATTCTG
CGTGTGCTCCACCAAAAACAAAAATTCCCTACAGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11022.34 Da        Isoelectric Point: 8.0517

>AT30164 WP_004404015.1 NC_022543:2198755-2199039 [Vibrio nigripulchritudo]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKLDSGKSVFVEHESAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT30164 NC_022543:2198755-2199039 [Vibrio nigripulchritudo]
ATGGACACTAGAATTCAGTTTCGTGTTGATGAGGAAACAAAACGCTTAGCTCAGCAAATGGCTGAAAGCCAGGGTCGTAC
TTTGAGTGATGCTTGCCGAGAACTTACTGAACAACTCGCTGAACAACAAAGAAAAACACTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGCTTGACTCAGGAAAGTCGGTTTTCGTTGAACATGAATCGGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGCAACCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N3LLP7

Antitoxin

Source ID Structure
AlphaFold DB U4DQE1

References