Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 12109..12776 Replicon plasmid pla
Accession NC_022539
Organism Xanthomonas fuscans subsp. fuscans

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag XFF4834R_RS21055 Protein ID WP_022557732.1
Coordinates 12360..12776 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag XFF4834R_RS21050 Protein ID WP_022557731.1
Coordinates 12109..12363 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFF4834R_RS21035 7367..8281 - 915 WP_022557729.1 hypothetical protein -
XFF4834R_RS24180 8964..9068 + 105 Protein_11 type III secretion system effector protein -
XFF4834R_RS23600 9203..10255 + 1053 WP_022557730.1 type III secretion system YopJ family effector AvrBsT -
XFF4834R_RS21040 10389..11615 + 1227 WP_011345585.1 IS256-like element ISXax1 family transposase -
XFF4834R_RS21045 11652..11897 - 246 Protein_14 recombinase family protein -
XFF4834R_RS21050 12109..12363 + 255 WP_022557731.1 plasmid stability protein Antitoxin
XFF4834R_RS21055 12360..12776 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
XFF4834R_RS21060 12790..13344 + 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
XFF4834R_RS21065 13419..13556 - 138 Protein_18 transposase -
XFF4834R_RS21070 13626..14156 - 531 Protein_19 DNA topoisomerase III -
XFF4834R_RS21075 14308..15600 - 1293 WP_033481893.1 hypothetical protein -
XFF4834R_RS21080 15727..17046 - 1320 WP_022557736.1 DUF4990 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..45224 45224
- inside IScluster/Tn - - 10389..13556 3167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T30160 WP_022557732.1 NC_022539:12360-12776 [Xanthomonas citri pv. fuscans]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T30160 NC_022539:12360-12776 [Xanthomonas citri pv. fuscans]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT30160 WP_022557731.1 NC_022539:12109-12363 [Xanthomonas citri pv. fuscans]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT30160 NC_022539:12109-12363 [Xanthomonas citri pv. fuscans]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References