Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 772738..773282 Replicon chromosome
Accession NC_022535
Organism Rhizobium sp. IRBG74

Toxin (Protein)


Gene name parE Uniprot ID U4PRC3
Locus tag BN877_RS03715 Protein ID WP_004440407.1
Coordinates 772992..773282 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID U4PRA7
Locus tag BN877_RS03710 Protein ID WP_022555750.1
Coordinates 772738..772989 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN877_RS03685 767836..768525 - 690 WP_003520496.1 HAD family hydrolase -
BN877_RS03690 768740..769420 + 681 WP_004440402.1 GntR family transcriptional regulator -
BN877_RS03695 769461..769922 + 462 WP_022555748.1 DUF1284 domain-containing protein -
BN877_RS03700 769882..770982 - 1101 WP_022555749.1 hypothetical protein -
BN877_RS03705 771219..772364 + 1146 WP_004440405.1 site-specific DNA-methyltransferase -
BN877_RS03710 772738..772989 + 252 WP_022555750.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BN877_RS03715 772992..773282 + 291 WP_004440407.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BN877_RS03720 773314..773925 - 612 WP_022555751.1 HAD family phosphatase -
BN877_RS03725 773922..775025 - 1104 WP_022555752.1 A/G-specific adenine glycosylase -
BN877_RS03730 775123..775650 + 528 WP_022555753.1 DUF721 domain-containing protein -
BN877_RS03735 775779..776459 + 681 WP_006309853.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11253.77 Da        Isoelectric Point: 6.6456

>T30157 WP_004440407.1 NC_022535:772992-773282 [Rhizobium pusense]
MGFRLSLPAEEDVIRIAQEGIDLFGPQQARKYHRELFAIFDLISRNPRIARERNELSPSVRIHPFRAHLVVYRVEADDDV
LIVRVRHGHEDWGNEP

Download         Length: 291 bp

>T30157 NC_022535:772992-773282 [Rhizobium pusense]
ATGGGATTTCGCCTTTCTCTGCCTGCGGAAGAAGACGTCATCCGCATAGCGCAAGAAGGCATCGACCTATTTGGACCTCA
GCAAGCGCGAAAGTACCATCGCGAACTTTTCGCAATATTCGACTTGATATCACGGAATCCGAGGATCGCACGCGAGCGTA
ACGAGTTGTCGCCGTCGGTGCGCATTCATCCGTTCAGAGCACATCTGGTGGTCTATCGCGTTGAGGCGGACGACGACGTC
CTCATCGTCCGCGTCCGCCATGGGCACGAGGACTGGGGCAATGAGCCTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9316.56 Da        Isoelectric Point: 6.9801

>AT30157 WP_022555750.1 NC_022535:772738-772989 [Rhizobium pusense]
MVTMNISLPGQMKEWVEAQSKTGRYSNASDYVRDLIRKDQERSEKIAAMQGLVDEGLQAPSGHRCEDALFAEAEARSMKR
KIG

Download         Length: 252 bp

>AT30157 NC_022535:772738-772989 [Rhizobium pusense]
ATGGTGACCATGAATATTTCGCTGCCCGGCCAGATGAAGGAATGGGTCGAAGCGCAGTCTAAAACGGGCCGTTACTCCAA
TGCCAGCGACTATGTGCGAGATCTCATCCGAAAGGATCAGGAGCGGAGCGAAAAGATCGCTGCCATGCAGGGTCTGGTGG
ACGAAGGATTGCAGGCTCCCTCCGGTCATCGTTGTGAAGATGCCTTGTTTGCTGAGGCCGAAGCCCGCTCCATGAAACGT
AAAATTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U4PRC3

Antitoxin

Source ID Structure
AlphaFold DB A0A098RRB9

References