Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3434006..3434534 Replicon chromosome
Accession NC_022528
Organism Vibrio nigripulchritudo

Toxin (Protein)


Gene name relE Uniprot ID U4K9G0
Locus tag VIBNI_RS15510 Protein ID WP_005464658.1
Coordinates 3434244..3434534 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U4K213
Locus tag VIBNI_RS15505 Protein ID WP_022551768.1
Coordinates 3434006..3434254 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VIBNI_RS15475 3429460..3430152 + 693 WP_022551762.1 response regulator -
VIBNI_RS15480 3430152..3431519 + 1368 WP_022609536.1 envelope stress sensor histidine kinase CpxA -
VIBNI_RS15485 3431944..3432555 + 612 WP_022551764.1 superoxide dismutase -
VIBNI_RS15490 3432668..3433144 + 477 WP_022551765.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
VIBNI_RS15495 3433186..3433380 - 195 WP_022551766.1 hypothetical protein -
VIBNI_RS15500 3433466..3433840 - 375 WP_022551767.1 hypothetical protein -
VIBNI_RS15505 3434006..3434254 + 249 WP_022551768.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VIBNI_RS15510 3434244..3434534 + 291 WP_005464658.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VIBNI_RS15515 3435052..3435783 - 732 WP_022600724.1 hypothetical protein -
VIBNI_RS29180 3435814..3435942 - 129 WP_145975620.1 DUF3265 domain-containing protein -
VIBNI_RS15520 3435920..3436309 - 390 WP_022551770.1 hypothetical protein -
VIBNI_RS15525 3436517..3437560 + 1044 WP_022551771.1 IS110 family transposase -
VIBNI_RS15530 3438227..3438940 - 714 WP_022551772.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3436517..3437560 1043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11277.25 Da        Isoelectric Point: 10.5932

>T30149 WP_005464658.1 NC_022528:3434244-3434534 [Vibrio nigripulchritudo]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGSDNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T30149 NC_022528:3434244-3434534 [Vibrio nigripulchritudo]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCGCTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCAGCTTCAAAGCTTTCTGGATCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGGAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9019.29 Da        Isoelectric Point: 3.9610

>AT30149 WP_022551768.1 NC_022528:3434006-3434254 [Vibrio nigripulchritudo]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMVDKLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT30149 NC_022528:3434006-3434254 [Vibrio nigripulchritudo]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCTACTAGTGC
TTATGGCGAACCTGTTGCTGTATTAAACCGAAATGAGCCAGCATTCTATTGCGTACCTGCCGAAGCGTACGAAATGATGG
TGGACAAACTCGAAGATCTTGAACTACTAGCTATAGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N3LNF1

Antitoxin

Source ID Structure
AlphaFold DB A0A6N3LLX4

References